ArticleGenetics2003
Screens for piwi suppressors in Drosophila identify dosage-dependent regulators of germline stem cell division.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Epigenetic Alterations in Meningiomas-A Review.Biomedicines · 2026Review
- PIWI proteins and piRNAs: key regulators of stem cell biology.Frontiers in cell and developmental biology · 2025Review
- Article
- c-Fos Repression by Piwi Regulates Drosophila Ovarian Germline Formation and Tissue Morphogenesis.PLoS genetics · 2016Article
- Piwi maintains germline stem cells and oogenesis in Drosophila through negative regulation of Polycomb group proteins.Nature genetics · 2016Article
- Stem cell protein Piwil1 endowed endometrial cancer cells with stem-like properties via inducing epithelial-mesenchymal transition.BMC cancer · 2015Article
- Transposon defense by endo-siRNAs, piRNAs and somatic pilRNAs in Drosophila: contributions of Loqs-PD and R2D2.PloS one · 2014Article
- Separation of stem cell maintenance and transposon silencing functions of Piwi protein.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Small noncoding RNAs in the germline.Cold Spring Harbor perspectives in biology · 2011Review
- Article
- The members of bHLH transcription factor superfamily are required for female reproduction in the red flour beetle, Tribolium castaneum.Journal of insect physiology · 2010Article
- The biogenesis and function of PIWI proteins and piRNAs: progress and prospect.Annual review of cell and developmental biology · 2009Review
- Regulation of telomere length in Drosophila.Cytogenetic and genome research · 2008Review
- DjPiwi-1, a member of the PAZ-Piwi gene family, defines a subpopulation of planarian stem cells.Development genes and evolution · 2006Article
- Stem cell aging in the Drosophila ovary.Age (Dordrecht, Netherlands) · 2005Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The Drosophila piwi gene is the founding member of the only known family of genes whose function in stem cell maintenance is highly conserved in both animal and plant kingdoms. piwi mutants fail to maintain germline stem cells in both male and female gonads. The identification of piwi-interacting genes is essential for understanding how stem cell divisions are regulated by piwi-mediated mechanisms. To search for such genes, we screened the Drosophila third chromosome ( approximately 36% of the euchromatic genome) for suppressor mutations of piwi2 and identified six strong and three weak piwi suppressor genes/sequences. These genes/sequences interact negatively with piwi in a dosage-sensitive manner. Two of the strong suppressors represent known genes--serendipity-delta and similar, both encoding transcription factors. These findings reveal that the genetic regulation of germline stem cell division involves dosage-sensitive mechanisms and that such mechanisms exist at the transcriptional level. In addition, we identified three other types of piwi interactors. The first type consists of deficiencies that dominantly interact with piwi2 to cause male sterility, implying that dosage-sensitive regulation also exists in the male germline. The other two types are deficiencies that cause lethality and female-specific lethality in a piwi2 mutant background, revealing the zygotic function of piwi in somatic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.