ArticleGenetics2003
The Drosophila melanogaster importin alpha3 locus encodes an essential gene required for the development of both larval and adult tissues.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3.eLife · 2020Article
- R7 photoreceptor axon growth is temporally controlled by the transcription factor Ttk69, which inhibits growth in part by promoting transforming growth factor-β/activin signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- Birth, death, and replacement of karyopherins in Drosophila.Molecular biology and evolution · 2012Article
- Article
- Specific Cooperation Between Imp-α2 and Imp-β/Ketel in Spindle Assembly During Drosophila Early Nuclear Divisions.G3 (Bethesda, Md.) · 2012Article
- Distinct roles for classical nuclear import receptors in the growth of multinucleated muscle cells.Developmental biology · 2011Article
- Article
- Regulation of nucleocytoplasmic transport in skeletal muscle.Current topics in developmental biology · 2011Review
- Article
- Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors.BMC cell biology · 2010Article
- Evolution of the metazoan-specific importin alpha gene family.Journal of molecular evolution · 2009Article
- Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling.Developmental biology · 2008Article
- Analysis of the Drosophila melanogaster testes transcriptome reveals coordinate regulation of paralogous genes.Genetics · 2008Article
- Drosophila importin alpha1 performs paralog-specific functions essential for gametogenesis.Genetics · 2008Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nuclear transport of classical nuclear localization signal (cNLS)-containing proteins is mediated by the cNLS receptor importin alpha. The conventional importin alpha gene family in metazoan animals is composed of three clades that are conserved between flies and mammals and are referred to here as alpha1, alpha2, and alpha3. In contrast, plants and fungi contain only alpha1 genes. In this study we report that Drosophila importin alpha3 is required for the development of both larval and adult tissues. Importin alpha3 mutant flies die around the transition from first to second instar larvae, and homozygous importin alpha3 mutant eyes are defective. The transition to second instar larvae was rescued with importin alpha1, alpha2, or alpha3 transgenes, indicating that Importin alpha3 is normally required at this stage for an activity shared by all three importin alpha's. In contrast, an alpha3-specific biochemical activity(s) of Importin alpha3 is probably required for development to adults and photoreceptor cell development, since only an importin alpha3 transgene rescued these processes. These results are consistent with the view that the importin alpha's have both overlapping and distinct functions and that their role in animal development involves the spatial and temporal control of their expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.