ArticleGenetics2003
l(3)malignant brain tumor and three novel genes are required for Drosophila germ-cell formation.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Local nuclear to cytoplasmic ratio regulates H3.3 incorporation via cell cycle state during zygotic genome activation.EMBO reports · 2025Article
- Caspar modulates primordial germ cell fate both in an Oskar-dependent and Oskar-independent manner.Biology open · 2025Article
- Article
- Manipulating the nature of embryonic mitotic waves.Current biology : CB · 2022Article
- Cullin-5 mutants reveal collective sensing of the nucleocytoplasmic ratio in Drosophila embryogenesis.Current biology : CB · 2022Article
- Article
- Coordination of Embryogenesis by the Centrosome in Drosophila melanogaster.Results and problems in cell differentiation · 2019Review
- L(3)mbt and the LINT complex safeguard cellular identity in theDevelopment (Cambridge, England) · 2018Article
- Article
- RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.The EMBO journal · 2017Article
- AnOpen biology · 2017Article
- Loss of l(3)mbt leads to acquisition of the ping-pong cycle in Drosophila ovarian somatic cells.Genes & development · 2016Article
- microRNAs regulate cell-to-cell variability of endogenous target gene expression in developing mouse thymocytes.PLoS genetics · 2015Article
- Chromatin reader L(3)mbt requires the Myb-MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Methods for studying oogenesis.Methods (San Diego, Calif.) · 2014Review
- Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference.PloS one · 2014Article
- Maternal loss of miRNAs leads to increased variance in primordial germ cell numbers in Drosophila melanogaster.G3 (Bethesda, Md.) · 2013Article
- The complex containing Drosophila Myb and RB/E2F2 regulates cytokinesis in a histone H2Av-dependent manner.Molecular and cellular biology · 2013Article
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
To identify genes involved in the process of germ-cell formation in Drosophila, a maternal-effect screen using the FLP/FRT-ovoD method was performed on chromosome 3R. In addition to expected mutations in the germ-cell determinant oskar and in other genes known to be involved in the process, several novel mutations caused defects in germ-cell formation. Mutations in any of three genes [l(3)malignant brain tumor, shackleton, and out of sync] affect the synchronous mitotic divisions and nuclear migration of the early embryo. The defects in nuclear migration or mitotic synchrony result in a reduction in germ-cell formation. Mutations in another gene identified in this screen, bebra, do not cause mitotic defects, but appear to act upstream of the localization of oskar. Analysis of our mutants demonstrates that two unique and independent processes must occur to form germ cells-germ-plasm formation and nuclear division/migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.