ArticleGenetics2003
Selective constraints on intron evolution in Drosophila.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed.
- The Impact of Natural Selection on Short Insertion and Deletion Variation in the Great Tit Genome.Genome biology and evolution · 2019Article
- Analysis of the Functional Relevance of Epigenetic Chromatin Marks in the First Intron Associated with Specific Gene Expression Patterns.Genome biology and evolution · 2019Article
- Enrichment of rare alleles within epigenetic chromatin marks in the first intron.Genomics & informatics · 2019Article
- New Methods for Inferring the Distribution of Fitness Effects for INDELs and SNPs.Molecular biology and evolution · 2018Article
- A Large Panel of Drosophila simulans Reveals an Abundance of Common Variants.Genome biology and evolution · 2018Article
- The kinetics of pre-mRNA splicing in theeLife · 2017Article
- Article
- The effects of purifying selection on patterns of genetic differentiation between Drosophila melanogaster populations.Heredity · 2015Article
- Strong heterogeneity in mutation rate causes misleading hallmarks of natural selection on indel mutations in the human genome.Molecular biology and evolution · 2014Article
- Hybridization reveals the evolving genomic architecture of speciation.Cell reports · 2013Article
- Phylogenetics and Gene Structure Dynamics of Polygalacturonase Genes in Aspergillus and Neurospora crassa.The plant pathology journal · 2013Article
- Stabilizing selection, purifying selection, and mutational bias in finite populations.Genetics · 2013Article
- Strong mutational bias toward deletions in the Drosophila melanogaster genome is compensated by selection.Genome biology and evolution · 2013Article
- Origin and evolution of spliceosomal introns.Biology direct · 2012Review
- Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans.BMC genomics · 2012Article
- The genomic signature of splicing-coupled selection differs between long and short introns.Molecular biology and evolution · 2012Article
- Article
- Contrasting 5' and 3' evolutionary histories and frequent evolutionary convergence in Meis/hth gene structures.Genome biology and evolution · 2011Article
- Genetic and evolutionary correlates of fine-scale recombination rate variation in Drosophila persimilis.Journal of molecular evolution · 2010Article
- On the utility of short intron sequences as a reference for the detection of positive and negative selection in Drosophila.Molecular biology and evolution · 2010Article
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1 author.
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No grant is acknowledged in the PubMed record.
Abstract
Intron sizes show an asymmetrical distribution in a number of organisms, with a large number of "short" introns clustered around a minimal intron length and a much broader distribution of longer introns. In Drosophila melanogaster, the short intron class is centered around 61 bp. The narrow length distribution suggests that natural selection may play a role in maintaining intron size. A comparison of 15 orthologous introns among species of the D. melanogaster subgroup indicates that, in general, short introns are not under greater DNA sequence or length constraints than long introns. There is a bias toward deletions in all introns (deletion/insertion ratio is 1.66), and the vast majority of indels are of short length (<10 bp). Indels occurring on the internal branches of the phylogenetic tree are significantly longer than those occurring on the terminal branches. These results are consistent with a compensatory model of intron length evolution in which slightly deleterious short deletions are frequently fixed within species by genetic drift, and relatively rare larger insertions that restore intron length are fixed by positive selection. A comparison of paralogous introns shared among duplicated genes suggests that length constraints differ between introns within the same gene. The janusA, janusB, and ocnus genes share two short introns derived from a common ancestor. The first of these introns shows significantly fewer indels than the second intron, although the two introns show a comparable number of substitutions. This indicates that intron-specific selective constraints have been maintained following gene duplication, which preceded the divergence of the D. melanogaster species subgroup.
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