ArticleGenetics2003
The structure and early evolution of recently arisen gene duplicates in the Caenorhabditis elegans genome.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
86 citing papers in PubMed, 153 citations in OpenAlex.
- Evolutionary causes and consequences of gene duplication.Nature reviews. Genetics · 2026Review
- From duplication to divergence: Single-cell insights into transcriptional and cis-regulatory landscapes in soybean.The Plant cell · 2025Article
- Article
- Amplicon Remodeling and Genomic Mutations Drive Population Dynamics after Segmental Amplification.Molecular biology and evolution · 2022Article
- Genetic Divergence of Lineage-Specific Tandemly Duplicated Gene Clusters in Four Diploid Potato Genotypes.Frontiers in plant science · 2022Article
- Molecular Characterization and Functional Analysis of theFrontiers in physiology · 2021Article
- HSDFinder: A BLAST-Based Strategy for Identifying Highly Similar Duplicated Genes in Eukaryotic Genomes.Frontiers in bioinformatics · 2021Article
- Evolution of new enzymes by gene duplication and divergence.The FEBS journal · 2020Review
- The Genome of the Great Gerbil Reveals Species-Specific Duplication of an MHCII Gene.Genome biology and evolution · 2020Article
- The Genomic Substrate for Adaptive Radiation: Copy Number Variation across 12 Tribes of African Cichlid Species.Genome biology and evolution · 2019Article
- The Evolution and Biocatalysis of FAD2 Indicate Its Correlation to the Content of Seed Oil in Plants.International journal of molecular sciences · 2019Article
- Deep taxon sampling reveals the evolutionary dynamics of novel gene families inGenome research · 2018Article
- Adaptive deletion in resistance gene duplications in the malaria vectorEvolutionary applications · 2018Article
- Evolutionarily conserved partial gene duplication in the Triticeae tribe of grasses confers pathogen resistance.Genome biology · 2018Article
- Mutational and transcriptional landscape of spontaneous gene duplications and deletions inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Expansion of the IL1B gene family in the pig.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The Role of Retrotransposons in Gene Family Expansions in the Human and Mouse Genomes.Genome biology and evolution · 2016Article
- Copy number variation contributes to cryptic genetic variation in outbreak lineages of Cryptococcus gattii from the North American Pacific Northwest.BMC genomics · 2016Article
- Extracting functional trends from whole genome duplication events using comparative genomics.Biological procedures online · 2016Review
- Rapid Increase in frequency of gene copy-number variants during experimental evolution in Caenorhabditis elegans.BMC genomics · 2015Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The significance of gene duplication in provisioning raw materials for the evolution of genomic diversity is widely recognized, but the early evolutionary dynamics of duplicate genes remain obscure. To elucidate the structural characteristics of newly arisen gene duplicates at infancy and their subsequent evolutionary properties, we analyzed gene pairs with < or =10% divergence at synonymous sites within the genome of Caenorhabditis elegans. Structural heterogeneity between duplicate copies is present very early in their evolutionary history and is maintained over longer evolutionary timescales, suggesting that duplications across gene boundaries in conjunction with shuffling events have at least as much potential to contribute to long-term evolution as do fully redundant (complete) duplicates. The median duplication span of 1.4 kb falls short of the average gene length in C. elegans (2.5 kb), suggesting that partial gene duplications are frequent. Most gene duplicates reside close to the parent copy at inception, often as tandem inverted loci, and appear to disperse in the genome as they age, as a result of reduced survivorship of duplicates located in proximity to the ancestral copy. We propose that illegitimate recombination events leading to inverted duplications play a disproportionately large role in gene duplication within this genome in comparison with other mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.