ArticleGenetics2003
A conservative test of genetic drift in the endosymbiotic bacterium Buchnera: slightly deleterious mutations in the chaperonin groEL.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Hidden genetic diversity among Blochmanniella endosymbionts of closely related carpenter ant populations.Journal of evolutionary biology · 2026Article
- Genetic Covariation Between the Vertically Transmitted Endophyte Epichloë canadensis and Its Host Canada Wildrye.Microbial ecology · 2023Article
- Horizontal transmission and recombination maintain forever young bacterial symbiont genomes.PLoS genetics · 2020Article
- Polyclonal symbiont populations in hydrothermal vent tubeworms and the environment.Proceedings. Biological sciences · 2019Article
- Random Genetic Drift and Selective Pressures Shaping the Blattabacterium Genome.Scientific reports · 2018Article
- What Is Speciation?PLoS genetics · 2016Review
- Comparative Genomics of a Plant-Parasitic Nematode Endosymbiont Suggest a Role in Nutritional Symbiosis.Genome biology and evolution · 2015Article
- Heritable symbiosis: The advantages and perils of an evolutionary rabbit hole.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Endosymbiosis and its implications for evolutionary theory.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- RELAX: detecting relaxed selection in a phylogenetic framework.Molecular biology and evolution · 2015Article
- Circulation of four Anaplasma phagocytophilum ecotypes in Europe.Parasites & vectors · 2014Article
- Functional and evolutionary analysis of the genome of an obligate fungal symbiont.Genome biology and evolution · 2013Article
- Weak selection and protein evolution.Genetics · 2012Review
- The Presence of the DNA Repair Genes mutM, mutY, mutL, and mutS is Related to Proteome Size in Bacterial Genomes.Frontiers in genetics · 2012Article
- The analysis of groEL gene in Salmonella enterica subspecies enterica serovar Typhimurium isolated from avians by PCR-Restriction Fragment Length Polymorphism method.Veterinary research communications · 2011Article
- A unique group I intron in Coxiella burnetii is a natural splice mutant.Journal of bacteriology · 2009Article
- Interactions of chaperonin with a weakly active anthranilate synthase from the aphid endosymbiont Buchnera aphidicola.Microbial ecology · 2008Article
- DNA variation and symbiotic associations in phenotypically diverse sea urchin Strongylocentrotus intermedius.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Toxic introns and parasitic intein in Coxiella burnetii: legacies of a promiscuous past.Journal of bacteriology · 2008Article
- Reducing the false positive rate in the non-parametric analysis of molecular coevolution.BMC evolutionary biology · 2008Article
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4 authors.
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Abstract
The obligate endosymbiotic bacterium Buchnera aphidicola shows elevated rates of sequence evolution compared to free-living relatives, particularly at nonsynonymous sites. Because Buchnera experiences population bottlenecks during transmission to the offspring of its aphid host, it is hypothesized that genetic drift and the accumulation of slightly deleterious mutations can explain this rate increase. Recent studies of intraspecific variation in Buchnera reveal patterns consistent with this hypothesis. In this study, we examine inter- and intraspecific nucleotide variation in groEL, a highly conserved chaperonin gene that is constitutively overexpressed in Buchnera. Maximum-likelihood estimates of nonsynonymous substitution rates across Buchnera species are strikingly low at groEL compared to other loci. Despite this evidence for strong purifying selection on groEL, our intraspecific analysis of this gene documents reduced synonymous polymorphism, elevated nonsynonymous polymorphism, and an excess of rare alleles relative to the neutral expectation, as found in recent studies of other Buchnera loci. Comparisons with Escherichia coli generally show patterns predicted by their differences in N(e). The sum of these observations is not expected under relaxed or balancing selection, selective sweeps, or increased mutation rate. Rather, they further support the hypothesis that drift is an important force driving accelerated protein evolution in this obligate mutualist.
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