ReviewInternational journal of hematology2003
The role of the MLL gene in infant leukemia.
Review in International journal of hematology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Germline Variants and Characteristic Features of Hereditary Hematological Malignancy Syndrome.International journal of molecular sciences · 2024Review
- Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation byCancers · 2020Article
- Article
- Topoisomerase II and leukemia.Annals of the New York Academy of Sciences · 2014Review
- Targeting recruitment of disruptor of telomeric silencing 1-like (DOT1L): characterizing the interactions between DOT1L and mixed lineage leukemia (MLL) fusion proteins.The Journal of biological chemistry · 2013Article
- MLL-AF9-mediated immortalization of human hematopoietic cells along different lineages changes during ontogeny.Leukemia · 2013Article
- Flt3 does not play a critical role in murine myeloid leukemias induced by MLL fusion genes.PloS one · 2013Article
- A soluble form of CTLA-4 is present in paediatric patients with acute lymphoblastic leukaemia and correlates with CD1d+ expression.PloS one · 2012Article
- Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias.The Journal of biological chemistry · 2010Article
- AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel alpha.The Journal of biological chemistry · 2009Article
- Chromosomal rearrangements leading to MLL gene fusions: clinical and biological aspects.Cancer research · 2008Review
- HYBRIDdb: a database of hybrid genes in the human genome.BMC genomics · 2007Article
- Review
- Molecular pathogenesis of MLL-associated leukemias.International journal of hematology · 2005Review
- Article
- Roles of a trithorax group gene, MLL, in hematopoiesis.International journal of hematology · 2005Review
- CD1d expression on B-precursor acute lymphoblastic leukemia subsets with poor prognosis.Leukemia · 2005Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The MLL gene is a major player in leukemia, particularly in infant leukemia and in secondary, therapy-related acute leukemia. The normal MLL gene plays a key role in developmental regulation of gene expression (including HOX genes), and in leukemia this function is subverted by breakage, recombination, and chimeric fusion with one of 40 or more alternative partner genes. In infant leukemias, the chromosome translocations involving MLL arise during fetal hematopoiesis, possibly in a primitive lymphomyeloid stem cell. In general, these leukemias have a very poor prognosis. The malignancy of these leukemias is all the more dramatic considering their very short preclinical natural history or latency. These data raise fundamental issues of how such divergent MLL chimeric genes transform cells, why they so rapidly evolve to a malignant status, and what alternative or novel therapeutic strategies might be considered. We review here progress in tackling these questions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.