ReviewChemical communications (Cambridge, England)2003
Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling.
Review in Chemical communications (Cambridge, England), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
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- Psychoactive substances: novel molecular insights and therapeutic potential for Alzheimer's disease.Translational neurodegeneration · 2025Review
- The Neuroprotective Effects of Moderate and Regular Caffeine Consumption in Alzheimer's Disease.Oxidative medicine and cellular longevity · 2021Review
- The neuroprotective effects of caffeine in neurodegenerative diseases.CNS neuroscience & therapeutics · 2017Review
- Article
- Molecular Docking and Prediction of Pharmacokinetic Properties of Dual Mechanism Drugs that Block MAO-B and Adenosine A(2A) Receptors for the Treatment of Parkinson's Disease.Journal of young pharmacists : JYP · 2012Article
- Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach.BMC structural biology · 2010Article
- The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.Science (New York, N.Y.) · 2008Article
- GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors.BMC bioinformatics · 2008Article
- Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: Effect of the N-5 bond type on the affinity and selectivity at the four adenosine receptor subtypes.Purinergic signalling · 2008Article
- Prediction of the 3-D structure of rat MrgA G protein-coupled receptor and identification of its binding site.Journal of molecular graphics & modelling · 2007Article
- Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: A complete structure-activity profile.Purinergic signalling · 2007Article
- Progress in the pursuit of therapeutic adenosine receptor antagonists.Medicinal research reviews · 2006Review
- Exploring human adenosine A3 receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety.Bioorganic & medicinal chemistry · 2005Article
- Techniques: Recent developments in computer-aided engineering of GPCR ligands using the human adenosine A3 receptor as an example.Trends in pharmacological sciences · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
We review our recent work on adenosine receptors, a family of GPCRs; focusing our attention on A3 adenosine receptor, we have demonstrated that the reciprocal integration of different theoretical and experimental disciplines can be very useful for the successful protein-based design of new, potent and selective receptor ligands.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.