ArticleJournal of bacteriology2004
Structural and genetic characterization of the Shigella boydii type 13 O antigen.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 83 citations in OpenAlex.
- Article
- Hierarchical sets: analyzing pangenome structure through scalable set visualizations.Bioinformatics (Oxford, England) · 2017Article
- Six Novel O Genotypes from Shiga Toxin-Producing Escherichia coli.Frontiers in microbiology · 2016Article
- Diversity of o-antigen repeat unit structures can account for the substantial sequence variation of wzx translocases.Journal of bacteriology · 2014Article
- A novel multiplex PCR for the simultaneous detection of Salmonella enterica and Shigella species.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- Genetic study of capsular switching between Neisseria meningitidis sequence type 7 serogroup A and C strains.Infection and immunity · 2010Article
- DNA microarray-based identification of serogroups and virulence gene patterns of Escherichia coli isolates associated with porcine postweaning diarrhea and edema disease.Applied and environmental microbiology · 2007Article
- Characterization of E. coli O24 and O56 O antigen gene clusters reveals a complex evolutionary history of the O24 gene cluster.Current microbiology · 2006Article
- Development of a serotype-specific DNA microarray for identification of some Shigella and pathogenic Escherichia coli strains.Journal of clinical microbiology · 2006Article
- Development of PCR assays targeting the genes involved in synthesis and assembly of the new Escherichia coli O 174 and O 177 O antigens.Journal of clinical microbiology · 2005Article
- Structural and genetic characterization of the Shigella boydii type 10 and type 6 O antigens.Journal of bacteriology · 2005Article
- Sequence analysis of the Escherichia coli O15 antigen gene cluster and development of a PCR assay for rapid detection of intestinal and extraintestinal pathogenic E. coli O15 strains.Journal of clinical microbiology · 2005Article
- Structural and genetic characterization of enterohemorrhagic Escherichia coli O145 O antigen and development of an O145 serogroup-specific PCR assay.Journal of bacteriology · 2005Article
- Evolutionary genetics of a new pathogenic Escherichia species: Escherichia albertii and related Shigella boydii strains.Journal of bacteriology · 2005Article
- Synthesis of the heteropolysaccharide O antigen of Escherichia coli O52 requires an ABC transporter: structural and genetic evidence.Journal of bacteriology · 2004Article
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shigella is an important human pathogen. It is generally agreed that Shigella and Escherichia coli constitute a single species; the only exception is Shigella boydii type 13, which is more distantly related to E. coli and other Shigella forms and seems to represent another species. This gives S. boydii type 13 an important status in evolution. O antigen is the polysaccharide part of the lipopolysaccharide in the outer membrane of gram-negative bacteria and plays an important role in pathogenicity. The chemical structure and genetic organization of the S. boydii type 13 O antigen were investigated. The O polysaccharide was found to be acid labile owing to the presence of a glycosyl phosphate linkage in the main chain. The structure of the linear pentasaccharide phosphate repeating unit (O unit) was established by nuclear magnetic resonance spectroscopy, including two-dimensional COSY, TOCSY, ROESY, and H-detected 1H, 13C and 1H, 31P HMQC experiments, along with chemical methods. The O antigen gene cluster of S. boydii type 13 was located and sequenced. Genes for synthesis of UDP-2-acetamido-2,6-dideoxy-L-glucose and genes that encode putative sugar transferases, O unit flippase, and O antigen polymerase were identified. Seven genes were found to be specific to S. boydii type 13. The S. boydii type 13 O antigen gene cluster has higher levels of sequence similarity with Vibrio cholerae gene clusters and may be evolutionarily related to these gene clusters.
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