ArticleJournal of bacteriology2004
Helicobacter acinonychis: genetic and rodent infection studies of a Helicobacter pylori-like gastric pathogen of cheetahs and other big cats.
Article in Journal of bacteriology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Molecular characterization of fourGut microbes · 2025Article
- Prevalence and diversity of Helicobacter species in captive wild carnivores, and their implications for conservation management of endangered species.BMC veterinary research · 2025Article
- Chronic Stress-Related Gastroenteric Pathology in Cheetah: Relation between Intrinsic and Extrinsic Factors.Biology · 2022Review
- Flavodoxins as Novel Therapeutic Targets againstInternational journal of molecular sciences · 2020Review
- Review
- Recombinant Bacillus subtilis Spores Elicit Th1/Th17-Polarized Immune Response in a Murine Model of Helicobacter pylori Vaccination.Molecular biotechnology · 2015Article
- Sequence divergence and conservation in genomes of Helicobacter cetorum strains from a dolphin and a whale.PloS one · 2013Article
- Electron microscopic, genetic and protein expression analyses of Helicobacter acinonychis strains from a Bengal tiger.PloS one · 2013Article
- Genome sequence of Helicobacter suis supports its role in gastric pathology.Veterinary research · 2011Article
- Molecular evolution of the Helicobacter pylori vacuolating toxin gene vacA.Journal of bacteriology · 2010Article
- Expression and display of UreA of Helicobacter acinonychis on the surface of Bacillus subtilis spores.Microbial cell factories · 2010Article
- Comparative genomics of Helicobacter pylori.World journal of gastroenterology · 2009Review
- Failure to detect Helicobacter pylori DNA in drinking and environmental water in Dhaka, Bangladesh, using highly sensitive real-time PCR assays.Applied and environmental microbiology · 2009Article
- DNA-level diversity and relatedness of Helicobacter pylori strains in shantytown families in Peru and transmission in a developing-country setting.Journal of clinical microbiology · 2008Article
- Helicobacter pylori evolution: lineage- specific adaptations in homologs of eukaryotic Sel1-like genes.PLoS computational biology · 2007Article
- Article
- Who ate whom? Adaptive Helicobacter genomic changes that accompanied a host jump from early humans to large felines.PLoS genetics · 2006Article
- Pathogenesis of Helicobacter pylori infection.Clinical microbiology reviews · 2006Review
- Gain and loss of multiple genes during the evolution of Helicobacter pylori.PLoS genetics · 2005Article
- Age-dependent changes in susceptibility of suckling mice to individual strains of Helicobacter pylori.Infection and immunity · 2005Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Insights into bacterium-host interactions and genome evolution can emerge from comparisons among related species. Here we studied Helicobacter acinonychis (formerly H. acinonyx), a species closely related to the human gastric pathogen Helicobacter pylori. Two groups of strains were identified by randomly amplified polymorphic DNA fingerprinting and gene sequencing: one group from six cheetahs in a U.S. zoo and two lions in a European circus, and the other group from a tiger and a lion-tiger hybrid in the same circus. PCR and DNA sequencing showed that each strain lacked the cag pathogenicity island and contained a degenerate vacuolating cytotoxin (vacA) gene. Analyses of nine other genes (glmM, recA, hp519, glr, cysS, ppa, flaB, flaA, and atpA) revealed a approximately 2% base substitution difference, on average, between the two H. acinonychis groups and a approximately 8% difference between these genes and their homologs in H. pylori reference strains such as 26695. H. acinonychis derivatives that could chronically infect mice were selected and were found to be capable of persistent mixed infection with certain H. pylori strains. Several variants, due variously to recombination or new mutation, were found after 2 months of mixed infection. H. acinonychis ' modest genetic distance from H. pylori, its ability to infect mice, and its ability to coexist and recombine with certain H. pylori strains in vivo should be useful in studies of Helicobacter infection and virulence mechanisms and studies of genome evolution.
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