ArticleThe Journal of clinical investigation2004
Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient.
Article in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 116 citations in OpenAlex.
- Is the NOD mouse a good model for type 1 diabetes?Diabetologia · 2026Review
- Traumatic spinal cord injury and its correlation to risk of autoimmune/-inflammatory disease.Spinal cord · 2024Article
- Network approach reveals preferential T-cell and macrophage association with α-linked β-cells in early stage of insulitis in NOD mice.Frontiers in network physiology · 2024Article
- Microbial (co)infections: Powerful immune influencers.PLoS pathogens · 2022Review
- Lower risk of primary Sjogren's syndrome in patients with dengue virus infection: a nationwide cohort study in Taiwan.Clinical rheumatology · 2021Observational
- Chemokines as Drivers of the Autoimmune Destruction in Type 1 Diabetes: Opportunity for Therapeutic Intervention in Consideration of an Optimal Treatment Schedule.Frontiers in endocrinology · 2020Review
- Viral Infections and Autoimmune Disease: Roles of LCMV in Delineating Mechanisms of Immune Tolerance.Viruses · 2019Review
- Pathogen infection and autoimmune disease.Clinical and experimental immunology · 2019Article
- Autoantibodies in Autoimmune Hepatitis: Can Epitopes Tell Us about the Etiology of the Disease?Frontiers in immunology · 2018Review
- Viral infections in type 1 diabetes mellitus--why the β cells?Nature reviews. Endocrinology · 2016Review
- Population dynamics of islet-infiltrating cells in autoimmune diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Beta-cell specific production of IL6 in conjunction with a mainly intracellular but not mainly surface viral protein causes diabetes.Journal of autoimmunity · 2014Article
- FC-98 regulates TLR9-mediated of CXCL-10 expression in dendritic cells via MAPK and STAT1 signaling pathway.BioMed research international · 2014Article
- Article
- Viruses and Type 1 diabetes: a dynamic labile equilibrium.Diabetes management (London, England) · 2013Article
- Influence of the vitamin D plasma level and vitamin D-related genetic polymorphisms on the immune status of patients with type 1 diabetes: a pilot study.Clinical and experimental immunology · 2013Article
- Article
- Blockade but not overexpression of the junctional adhesion molecule C influences virus-induced type 1 diabetes in mice.PloS one · 2013Article
- Prevention or acceleration of type 1 diabetes by viruses.Cellular and molecular life sciences : CMLS · 2013Review
- Acceleration of diabetes development in CXC chemokine receptor 3 (CXCR3)-deficient NOD mice.Diabetologia · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Viruses can cause but can also prevent autoimmune disease. This dualism has certainly hampered attempts to establish a causal relationship between viral infections and type 1 diabetes (T1D). To develop a better mechanistic understanding of how viruses can influence the development of autoimmune disease, we exposed prediabetic mice to various viral infections. We used the well-established NOD and transgenic RIP-LCMV models of autoimmune diabetes. In both cases, infection with the lymphocytic choriomeningitis virus (LCMV) completely abrogated the diabetic process. Interestingly, such therapeutic viral infections resulted in a rapid recruitment of T lymphocytes from the islet infiltrate to the pancreatic draining lymph node, where increased apoptosis was occurring. In both models this was associated with a selective and extensive expression of the chemokine IP-10 (CXCL10), which predominantly attracts activated T lymphocytes, in the pancreatic draining lymph node, and in RIP-LCMV mice it depended on the viral antigenic load. In RIP-LCMV mice, blockade of TNF-alpha or IFN-gamma in vivo abolished the prevention of T1D. Thus, virally induced proinflammatory cytokines and chemokines can influence the ongoing autoaggressive process beneficially at the preclinical stage, if produced at the correct location, time, and levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.