ArticleProceedings of the National Academy of Sciences of the United States of America2004
Pattern of diversity in the genomic region near the maize domestication gene tb1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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116 citing papers in PubMed.
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- Genome-wide association mapping and genomic prediction analyses reveal the genetic architecture of grain yield and agronomic traits under drought and optimum conditions in maize.BMC plant biology · 2025Article
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- Comparative population genomics reveals convergent and divergent selection in the apricot-peach-plum-mei complex.Horticulture research · 2024Article
- Large haplotypes highlight a complex age structure within the maize pan-genome.Genome research · 2023Article
- Identification of candidate genes associated with less-photosensitive anthocyanin phenotype using an EMS mutant (Frontiers in plant science · 2023Article
- The power of classic maize mutants: Driving forward our fundamental understanding of plants.The Plant cell · 2022Review
- Study on SupergenusPlants (Basel, Switzerland) · 2022Review
- Gene network simulations provide testable predictions for the molecular domestication syndrome.Genetics · 2022Article
- How Could the Use of Crop Wild Relatives in Breeding Increase the Adaptation of Crops to Marginal Environments?Frontiers in plant science · 2022Review
- Fine mapping and candidate gene analysis of the up locus determining fruit orientation in pepper (Capsicum spp.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Genetic Diversity, Structure, and Selective Sweeps inFrontiers in genetics · 2021Article
- Identification, Association of Natural Variation and Expression Analysis ofPlants (Basel, Switzerland) · 2020Article
- The genetic architecture of the maize progenitor, teosinte, and how it was altered during maize domestication.PLoS genetics · 2020Article
- Selective sweeps on novel and introgressed variation shape mimicry loci in a butterfly adaptive radiation.PLoS biology · 2020Article
- Identification of Selective Sweeps in the Domesticated Table and Wine Grape (Frontiers in plant science · 2020Article
- Global Role of Crop Genomics in the Face of Climate Change.Frontiers in plant science · 2020Review
56 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
Domesticated maize and its wild ancestor (teosinte) differ strikingly in morphology and afford an opportunity to examine the connection between strong selection and diversity in a major crop species. The tb1 gene largely controls the increase in apical dominance in maize relative to teosinte, and a region of the tb1 locus 5' to the transcript sequence was a target of selection during maize domestication. To better characterize the impact of selection at a major "domestication" locus, we have sequenced the upstream tb1 genomic region and systematically sampled nucleotide diversity for sites located as far as 163 kb upstream to tb1. Our analyses define a selective sweep of approximately 60-90 kb 5' to the tb1 transcribed sequence. The selected region harbors a mixture of unique sequences and large repetitive elements, but it contains no predicted genes. Diversity at the nearest 5' gene to tb1 is typical of that for neutral maize loci, indicating that selection at tb1 has had a minimal impact on the surrounding chromosomal region. Our data also show low intergenic linkage disequilibrium in the region and suggest that selection has had a minor role in shaping the pattern of linkage disequilibrium that is observed. Finally, our data raise the possibility that maize-like tb1 haplotypes are present in extant teosinte populations, and our findings also suggest a model of tb1 gene regulation that differs from traditional views of how plant gene expression is controlled.
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