ArticleProceedings of the National Academy of Sciences of the United States of America2004
Association of beta-catenin with the alpha-subunit of neuronal large-conductance Ca2+-activated K+ channels.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- The Physiological and Pathological Mechanisms of LIN2, LIN7, LIN10 and Their Tripartite Complex.Journal of cellular and molecular medicine · 2025Review
- BK Channel Deficiency in Osteoblasts Reduces Bone Formation via the Wnt/β-Catenin Pathway.Molecules and cells · 2021Article
- Immunohistochemical Analysis of CYP11B2, CYP11B1 and β-catenin Helps Subtyping and Relates With Clinical Characteristics of Unilateral Primary Aldosteronism.Frontiers in molecular biosciences · 2021Article
- Identifying HIPK1 as Target of miR-22-3p Enhancing Recombinant Protein Production From HEK 293 Cell by Using Microarray and HTP siRNA Screen.Biotechnology journal · 2018Article
- A Critical Role for β-Catenin in Modulating Levels of Insulin Secretion from β-Cells by Regulating Actin Cytoskeleton and Insulin Vesicle Localization.The Journal of biological chemistry · 2016Article
- Alcohol Regulates BK Surface Expression via Wnt/β-Catenin Signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- MaxiK channel and cell signalling.Pflugers Archiv : European journal of physiology · 2014Review
- GSK3 and β-catenin determines functional expression of sodium channels at the axon initial segment.Cellular and molecular life sciences : CMLS · 2013Article
- Stimulation of HERG channel activity by β-catenin.PloS one · 2012Article
- Interactions between β-catenin and the HSlo potassium channel regulates HSlo surface expression.PloS one · 2011Article
- Developmental expression of BK channels in chick cochlear hair cells.BMC developmental biology · 2009Article
- A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea.Molecular & cellular proteomics : MCP · 2009Article
- Deletion of CASK in mice is lethal and impairs synaptic function.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Nanodomains of single Ca2+ channels contribute to action potential repolarization in cortical neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- MaxiK channel partners: physiological impact.The Journal of physiology · 2006Review
- Identification and functional characterization of ankyrin-repeat family protein ANKRA as a protein interacting with BKCa channel.Molecular biology of the cell · 2005Article
- Hair cells--beyond the transducer.The Journal of membrane biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The association of Ca(2+)-activated K(+) channels with voltage-gated Ca(2+) channels at the presynaptic active zones of hair cells, photoreceptors, and neurons contributes to rapid repolarization of the membrane after excitation. Ca(2+) channels have been shown to bind to a large set of synaptic proteins, but the proteins interacting with Ca(2+)-activated K(+) channels remain unknown. Here, we report that the large-conductance Ca(2+)-activated K(+) channel of the chicken's cochlear hair cell interacts with beta-catenin. Yeast two-hybrid assays identified the S10 region of the K(+) channel's alpha-subunit and the ninth armadillo repeat and carboxyl terminus of beta-catenin as necessary for the interaction. An antiserum directed against the alpha-subunit specifically coprecipitated beta-catenin from brain synaptic proteins. beta-Catenin is known to associate with the synaptic protein Lin7/Velis/MALS, whose interaction partner Lin2/CASK also binds voltage-gated Ca(2+) channels. beta-Catenin may therefore provide a physical link between the two types of channels at the presynaptic active zone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.