ArticleProceedings of the National Academy of Sciences of the United States of America2004
Identification of calcium- and nitric oxide-regulated genes by differential analysis of library expression (DAzLE).
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Isolated Bacillus subtilis strain 330-2 and its antagonistic genes identified by the removing PCR.Scientific reports · 2017Article
- Identification of low Ca(2+) stress-induced embryo apoptosis response genes in Arachis hypogaea by SSH-associated library lift (SSHaLL).Plant biotechnology journal · 2016Article
- The neuronal activity-driven transcriptome.Molecular neurobiology · 2015Review
- Research progress on neurobiology of neuronal nitric oxide synthase.Neuroscience bulletin · 2011Review
- p38 mitogen-activated protein kinase and calcium channels mediate signaling in depolarization-induced activation of peroxisome proliferator-activated receptor gamma coactivator-1alpha in neurons.Journal of neuroscience research · 2010Article
- The endoplasmic reticulum exit of glutamate transporter is regulated by the inducible mammalian Yip6b/GTRAP3-18 protein.The Journal of biological chemistry · 2008Article
- Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system.Annual review of neuroscience · 2008Review
- Exon expression profiling reveals stimulus-mediated exon use in neural cells.Genome biology · 2007Article
- Identification and analysis of plasticity-induced late-response genes.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Suppression subtractive hybridization coupled with microarray analysis to examine differential expression of genes in virus infected cells.Biological procedures onlineArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Using a method of expression profiling called differential analysis of cDNA library expression (DAzLE), we report the expression profile of late response genes in a model of activity-dependent neuronal survival and neurite outgrowth. Using DAzLE, we isolated differentially expressed genes from cultured rat embryonic cortical neurons after KCl (50 mM)-mediated membrane depolarization. We identified 469 activity-dependent regulated genes, of which 174 are genes of unknown function. The regulation of 63 genes was found to be nitric oxide (NO)-dependent. Identifiable genes fell into several major categories, including signal transduction pathways, neuronal development, DNA replication, gene transcription, protein metabolism, energy regulatory proteins, and antiapoptotic proteins. These genes may be important in activity-dependent neuron survival and development. Furthermore, these late response genes provide the tools to begin to investigate downstream events in activity-dependent neuronal survival and development. The major advantage of DAzLE is that it provides a nearly complete and relatively comprehensive differential screening profile that has the potential to be a powerful and useful tool in other fields of study.
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