ArticleMolecular and cellular biology2004
Telomere cap components influence the rate of senescence in telomerase-deficient yeast cells.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- TERRA and Telomere Maintenance in the YeastGenes · 2023Review
- Set1 regulates telomere function via H3K4 methylation-dependent and -independent pathways and calibrates the abundance of telomere maintenance factors.Molecular biology of the cell · 2023Article
- Features and factors that dictate if terminating ribosomes cause or counteract nonsense-mediated mRNA decay.The Journal of biological chemistry · 2022Review
- Overlapping open reading frames strongly reduce human and yeast STN1 gene expression and affect telomere function.PLoS genetics · 2018Article
- Regulation of telomere metabolism by the RNA processing protein Xrn1.Nucleic acids research · 2017Article
- Cell cycle control (and more) by programmed -1 ribosomal frameshifting: implications for disease and therapeutics.Cell cycle (Georgetown, Tex.) · 2015Article
- Rad9 interacts with Aft1 to facilitate genome surveillance in fragile genomic sites under non-DNA damage-inducing conditions in S. cerevisiae.Nucleic acids research · 2014Article
- Multiple genetic pathways regulate replicative senescence in telomerase-deficient yeast.Aging cell · 2013Article
- Yeast telomere maintenance is globally controlled by programmed ribosomal frameshifting and the nonsense-mediated mRNA decay pathway.Translation (Austin, Tex.) · 2013Article
- Recombination can either help maintain very short telomeres or generate longer telomeres in yeast cells with weak telomerase activity.Eukaryotic cell · 2011Article
- Genome-wide analysis to identify pathways affecting telomere-initiated senescence in budding yeast.G3 (Bethesda, Md.) · 2011Article
- Quantitative fitness analysis shows that NMD proteins and many other protein complexes suppress or enhance distinct telomere cap defects.PLoS genetics · 2011Article
- Endogenous ribosomal frameshift signals operate as mRNA destabilizing elements through at least two molecular pathways in yeast.Nucleic acids research · 2011Article
- TERRA: telomeric repeat-containing RNA.The EMBO journal · 2009Review
- Yeast telomere capping protein Stn1 overrides DNA replication control through the S phase checkpoint.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Article
- A genome wide analysis of the response to uncapped telomeres in budding yeast reveals a novel role for the NAD+ biosynthetic gene BNA2 in chromosome end protection.Genome biology · 2008Article
- Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response.The EMBO journal · 2008Article
- The multiple lives of NMD factors: balancing roles in gene and genome regulation.Nature reviews. Genetics · 2008Review
- Association of yeast Upf1p with direct substrates of the NMD pathway.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cells lacking telomerase undergo senescence, a progressive reduction in cell division that involves a cell cycle delay and culminates in "crisis," a period when most cells become inviable. In telomerase-deficient Saccharomyces cerevisiae cells lacking components of the nonsense-mediated mRNA decay (NMD) pathway (Upf1,Upf2, or Upf3 proteins), senescence is delayed, with crisis occurring approximately 10 to 25 population doublings later than in Upf+ cells. Delayed senescence is seen in upfDelta cells lacking the telomerase holoenzyme components Est2p and TLC1 RNA, as well as in cells lacking the telomerase regulators Est1p and Est3p. The delay of senescence in upfDelta cells is not due to an increased rate of survivor formation. Rather, it is caused by alterations in the telomere cap, composed of Cdc13p, Stn1p, and Ten1p. In upfDelta mutants, STN1 and TEN1 levels are increased. Increasing the levels of Stn1p and Ten1p in Upf+ cells is sufficient to delay senescence. In addition, cdc13-2 mutants exhibit delayed senescence rates similar to those of upfDelta cells. Thus, changes in the telomere cap structure are sufficient to affect the rate of senescence in the absence of telomerase. Furthermore, the NMD pathway affects the rate of senescence in telomerase-deficient cells by altering the stoichiometry of telomere cap components.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.