ArticleMolecular and cellular biology2004
Eaf3 regulates the global pattern of histone acetylation in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 70 citations in OpenAlex.
- Genetic analysis of polyadenylation patterns reveals distinct classes of yeast genes and local chromatin effects on Pol II elongation.Genetics · 2026Article
- Chromatin regulator Eaf3p regulates nitrogen metabolism inApplied and environmental microbiology · 2023Article
- Chromatin Regulators Ahc1p and Eaf3p Positively Influence Nitrogen Metabolism inFrontiers in microbiology · 2022Article
- The Eaf3 chromodomain acts as a pH sensor for gene expression by altering its binding affinity for histone methylated-lysine residues.Bioscience reports · 2020Article
- Insights Into the Function of the NuA4 Complex in Plants.Frontiers in plant science · 2020Review
- The Eaf3/5/7 Subcomplex Stimulates NuA4 Interaction with Methylated Histone H3 Lys-36 and RNA Polymerase II.The Journal of biological chemistry · 2016Article
- Histone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast.Nucleic acids research · 2016Article
- Eaf1p Is Required for Recruitment of NuA4 in Targeting TFIID to the Promoters of the Ribosomal Protein Genes for Transcriptional Initiation In Vivo.Molecular and cellular biology · 2015Article
- Proteasome regulation of the chromodomain protein MRG-1 controls the balance between proliferative fate and differentiation in the C. elegans germ line.Development (Cambridge, England) · 2015Article
- Regulation of arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression.PLoS genetics · 2014Article
- Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling.The EMBO journal · 2014Article
- Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes.Nucleic acids research · 2014Article
- Epigenetic virtues of chromodomains.Critical reviews in biochemistry and molecular biology · 2011Review
- Domains of Tra1 important for activator recruitment and transcription coactivator functions of SAGA and NuA4 complexes.Molecular and cellular biology · 2011Article
- Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.Blood · 2010Article
- Histone chaperone Jun dimerization protein 2 (JDP2): role in cellular senescence and aging.The Kaohsiung journal of medical sciences · 2010Review
- GCN5 is a positive regulator of origins of DNA replication in Saccharomyces cerevisiae.PloS one · 2010Article
- MRG15 is a novel PALB2-interacting factor involved in homologous recombination.The Journal of biological chemistry · 2009Article
- Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae.BMC molecular biology · 2009Article
- H3 k36 methylation helps determine the timing of cdc45 association with replication origins.PloS one · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Saccharomyces cerevisiae has a global pattern of histone acetylation in which histone H3 and H4 acetylation levels are lower at protein-coding sequences than at promoter regions. The loss of Eaf3, a subunit of the NuA4 histone acetylase and Rpd3 histone deacetylase complexes, greatly alters the genomic profile of histone acetylation, with the effects on H4 appearing to be more pronounced than those on H3. Specifically, the loss of Eaf3 causes increases in H3 and H4 acetylation at coding sequences and decreases at promoters, such that histone acetylation levels become evenly distributed across the genome. Eaf3 does not affect the overall level of H4 acetylation, the recruitment of the NuA4 catalytic subunit Esa1 to target promoters, or the level of transcription of the genes analyzed for histone acetylation. Whole-genome transcriptional profiling indicates that Eaf3 plays a positive, but quantitatively modest, role in the transcription of a small subset of genes, whereas it has a negative effect on very few genes. We suggest that Eaf3 regulates the genomic profile of histone H3 and H4 acetylation in a manner that does not involve targeted recruitment and is independent of transcriptional activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.