ArticleMolecular and cellular biology2004
Analysis of a mutant histone H3 that perturbs the association of Swi/Snf with chromatin.
Article in Molecular and cellular biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Histone 3.3-related chromatinopathy: missense variants throughout H3-3A and H3-3B cause a range of functional consequences across species.Human genetics · 2024Review
- New twists of a TAIL: novel insights into the histone binding properties of a highly conserved PHD finger cluster within the MLR family of H3K4 mono-methyltransferases.Nucleic acids research · 2023Article
- Article
- Selective suppression of antisense transcription by Set2-mediated H3K36 methylation.Nature communications · 2016Article
- Divergent Residues Within Histone H3 Dictate a Unique Chromatin Structure in Saccharomyces cerevisiae.Genetics · 2016Article
- A systematic mutational analysis of a histone H3 residue in budding yeast provides insights into chromatin dynamics.G3 (Bethesda, Md.) · 2015Article
- A highly conserved region within H2B is important for FACT to act on nucleosomes.Molecular and cellular biology · 2014Article
- A nucleosomal region important for ensuring proper interactions between the transcription elongation factor Spt16 and transcribed genes in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2013Article
- Structure of the Spt16 middle domain reveals functional features of the histone chaperone FACT.The Journal of biological chemistry · 2013Article
- A DNA damage response system associated with the phosphoCTD of elongating RNA polymerase II.PloS one · 2013Article
- Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes.Nature · 2012Article
- Chromatin and transcription in yeast.Genetics · 2012Review
- A region of the nucleosome required for multiple types of transcriptional silencing in Saccharomyces cerevisiae.Genetics · 2011Article
- Article
- Silent information regulator 3: the Goldilocks of the silencing complex.Genes & development · 2010Review
- Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression.PLoS genetics · 2009Article
- Differential cofactor requirements for histone eviction from two nucleosomes at the yeast PHO84 promoter are determined by intrinsic nucleosome stability.Molecular and cellular biology · 2009Article
- HistoneHits: a database for histone mutations and their phenotypes.Genome research · 2009Article
- Uncoupling of the patterns of chromatin association of different transcription elongation factors by a histone H3 mutant in Saccharomyces cerevisiae.Eukaryotic cell · 2009Article
- Compensatory interactions between Sir3p and the nucleosomal LRS surface imply their direct interaction.PLoS genetics · 2008Article
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Authors and funding
2 authors.
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Abstract
We have isolated new histone H3 mutants in Saccharomyces cerevisiae that confer phenotypes indicative of transcriptional defects. Here we describe the characterization of one such mutant, encoded by the hht2-11 allele, which contains the single amino acid change L61W in the globular domain of H3. Whole-genome expression analyses show that the hht2-11 mutation confers pleiotropic transcriptional defects and that many of the genes it affects are normally controlled by the Swi/Snf chromatin remodeling complex. Furthermore, we show that Swi/Snf occupancy at two promoters, PHO84 and SER3, is reduced in hht2-11 mutants. Detailed studies of the PHO84 promoter suggest that the hht2-11 mutation impairs Swi/Snf association with chromatin in a direct fashion. Taken together, our results strongly suggest that the integrity of the globular domain of histone H3 is an important determinant in the ability of Swi/Snf to associate with chromatin.
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