ArticleMolecular psychiatry2004
Possible evidence for a common risk locus for bipolar affective disorder and schizophrenia on chromosome 4p16 in patients from the Faroe Islands.
Article in Molecular psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder.Molecular psychiatry · 2006Trial
- A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12.Molecular psychiatry · 2005Trial
- Article
- The Faroese IBD Study: Incidence of Inflammatory Bowel Diseases Across 54 Years of Population-based Data.Journal of Crohn's & colitis · 2016Article
- Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate.PLoS genetics · 2014Article
- Effect of chronic valproic Acid treatment on hepatic gene expression profile in wfs1 knockout mouse.PPAR research · 2014Article
- Article
- Wfs1 mutation makes mice sensitive to insulin-like effect of acute valproic acid and resistant to streptozocin.Journal of physiology and biochemistry · 2011Article
- Common variations in 4p locus are related to male completed suicide.Neuromolecular medicine · 2009Article
- Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia.Molecular psychiatry · 2007Article
- PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder.The pharmacogenomics journal · 2007Article
- Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia.Molecular psychiatry · 2006Article
- A genome-wide search for alleles and haplotypes associated with autism and related pervasive developmental disorders on the Faroe Islands.Molecular psychiatry · 2006Article
- Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.American journal of human genetics · 2004Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with schizophrenia (n=11) and bipolar affective disorder (n=17) from the relatively isolated population of the Faroe Islands were genotyped for 34 polymorphic markers on chromosome 4 in a search for allelic association and haplotype sharing among distantly related patients. When considering bipolar patients only, there was no clearcut support for any region on chromosome 4. The two-marker segment D4S394-D4S2983 at 4p16.1 was, however, supported by a P-value of 0.0162. For patients with schizophrenia, there was reasonable support for 4p16.1 as marker D4S2281 (P=0.0019), a two-marker segment (D4S2281-D4S1605, P=0.0009) and a three-marker segment (D4S2923-D4S2928-D4S1582, P-0.0005) appeared to be associated with schizophrenia, with some alleles/haplotypes occurring with different frequencies in patients compared to controls. When combining both psychiatric disorders, chromosome 4p16.1 received further support from five partially overlapping two- and three-marker segments (D4S394-D4S2983, P=0.0039; D4S2281-D4S1605, P=0.0027 and D4S394-D4S2983-D4S2923, P=0.006; D4S2923-D4S2928-D4S1582, P=0.00007; D4S1582-D4S1599-D4S2281, P=0.005). Increased haplotype sharing in patients with schizophrenia and in the combined data set was partly supported by Fisher's exact test and tests based on the genealogy. Our study yields support for a common risk gene for schizophrenia and bipolar affective disorder on the short arm of chromosome 4, as suggested by previous findings in the neighbouring Scottish population.
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