ArticleMolecular psychiatry2004
Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5.
Article in Molecular psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 5 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Mental health dished up-the use of iPSC models in neuropsychiatric research.Journal of neural transmission (Vienna, Austria : 1996) · 2020Pooled it
- DRD4 48 bp multiallelic variants as age-population-specific biomarkers in attention-deficit/hyperactivity disorder.Translational psychiatry · 2020Pooled it
- Association study and a systematic meta-analysis of the VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention-deficit hyperactivity disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2019Pooled it
- Role of dopamine receptors in ADHD: a systematic meta-analysis.Molecular neurobiology · 2012Pooled it
- Candidate gene studies of ADHD: a meta-analytic review.Human genetics · 2009Pooled it
- Neurobehavioral changes arising from early life dopamine signaling perturbations.Neurochemistry international · 2020Review
- Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Stressful Life Events, ADHD Symptoms, and Brain Structure in Early Adolescence.Journal of abnormal child psychology · 2019Article
- Genetic associations between ADHD and dopaminergic genes (DAT1 and DRD4) VNTRs in Korean children.Genes & genomics · 2018Article
- Application of Research Domain Criteria to childhood and adolescent impulsive and addictive disorders: Implications for treatment.Clinical psychology review · 2018Review
- Neuropsychological performance measures as intermediate phenotypes for attention-deficit/hyperactivity disorder: A multiple mediation analysis.Development and psychopathology · 2017Article
- Prenatal Alcohol Exposure in Rodents As a Promising Model for the Study of ADHD Molecular Basis.Frontiers in neuroscience · 2016Review
- DRD4 long allele carriers show heightened attention to high-priority items relative to low-priority items.Journal of cognitive neuroscience · 2015Article
- A parietal biomarker for ADHD liability: as predicted by the distributed effects perspective model of ADHD.Frontiers in psychiatry · 2015Article
- The role of prefrontal catecholamines in attention and working memory.Frontiers in neural circuits · 2014Review
- Two functional serotonin polymorphisms moderate the effect of food reinforcement on BMI.Behavioral neuroscience · 2013Article
- Catecholaminergic gene variants: contribution in ADHD and associated comorbid attributes in the eastern Indian probands.BioMed research international · 2013Article
- Attention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35.Biological psychiatry · 2010Article
- Personality mediation of genetic effects on Attention-Deficit/Hyperactivity Disorder.Journal of abnormal child psychology · 2010Article
- Familial clustering and DRD4 effects on electroencephalogram measures in multiplex families with attention deficit/hyperactivity disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2010Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Attention-deficit hyperactivity disorder (ADHD) is one of the most common childhood behavioral disorders. Genetic factors contribute to the underlying liability to develop ADHD. Reports implicate variants of genes important for the synthesis, uptake, transport and receptor binding of dopamine in the etiology of ADHD, including DRD4, DAT1, DRD2, and DRD5. In the present study, we genotyped a large multiplex sample of ADHD affected children and their parents for polymorphisms in genes previously reported to be associated with ADHD. Associations were tested by the transmission disequilibrium test (TDT). The sample is sufficient to detect genotype relative risks (GRRs) for putative risk alleles. The DRD4 gene 120-bp insertion/deletion promoter polymorphism displayed a significant bias in transmission of the insertion (chi(2)=7.58, P=0.006) as suggested by an analysis of a subset of these families. The seven repeat allele of the DRD4 48-bp repeat polymorphism (DRD4.7) was not significantly associated with ADHD in the large sample in contrast to our earlier findings in a smaller subset. We replicate an association of a dinucleotide repeat polymorphism near the DRD5 gene with ADHD by showing biased nontransmission of the 146-bp allele (P=0.02) and a trend toward excess transmission of the 148-bp allele (P=0.053). No evidence for an association was found for polymorphisms in DRD2 or DAT1 in this sample. The DRD5 146-bp (DRD5.146) allele and the DRD4 240-bp (DRD4.240) allele of the promoter polymorphism emerge as the two DNA variants showing a significant association in this large sample of predominantly multiplex families with ADHD, with estimated GRRs of 1.7 and 1.37, respectively.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.