ArticleMolecular psychiatry2004
Linkage analysis for autism in a subset families with obsessive-compulsive behaviors: evidence for an autism susceptibility gene on chromosome 1 and further support for susceptibility genes on chromosome 6 and 19.
Article in Molecular psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Glutamatergic candidate genes in autism spectrum disorder: an overview.Journal of neural transmission (Vienna, Austria : 1996) · 2014Pooled it
- A heterogeneity-based genome search meta-analysis for autism-spectrum disorders.Molecular psychiatry · 2006Pooled it
- Exploring key genes and pathways associated with sex differences in autism spectrum disorder: integrated bioinformatic analysis.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Autistic Traits as Predictors of Increased Obsessive-Compulsive Disorder Severity: The Role of Inflexibility and Communication Impairment.Brain sciences · 2024Article
- Protein Biomarkers of Autism Spectrum Disorder Identified by Computational and Experimental Methods.Frontiers in psychiatry · 2021Article
- Environmental and Genetic Factors in Autism Spectrum Disorders: Special Emphasis on Data from Arabian Studies.International journal of environmental research and public health · 2019Review
- White Matter Features Associated With Autistic Traits in Obsessive-Compulsive Disorder.Frontiers in psychiatry · 2018Article
- Bio-collections in autism research.Molecular autism · 2017Review
- Essential role of the nuclear isoform of RBFOX1, a candidate gene for autism spectrum disorders, in the brain development.Scientific reports · 2016Article
- Autism, Mitochondria and Polybrominated Diphenyl Ether Exposure.CNS & neurological disorders drug targets · 2016Review
- Variants of the CNTNAP2 5' promoter as risk factors for autism spectrum disorders: a genetic and functional approach.Molecular psychiatry · 2015Article
- A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity?Biological psychiatry · 2015Article
- Role of the cytoplasmic isoform of RBFOX1/A2BP1 in establishing the architecture of the developing cerebral cortex.Molecular autism · 2015Article
- Identification of rare DNA sequence variants in high-risk autism families and their prevalence in a large case/control population.Molecular autism · 2014Article
- Rare-variant extensions of the transmission disequilibrium test: application to autism exome sequence data.American journal of human genetics · 2014Article
- Haplotype structure enables prioritization of common markers and candidate genes in autism spectrum disorder.Translational psychiatry · 2013Article
- Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder.Molecular autism · 2013Article
- Identification of rare recurrent copy number variants in high-risk autism families and their prevalence in a large ASD population.PloS one · 2013Article
- Autism risk assessment in siblings of affected children using sex-specific genetic scores.Molecular autism · 2011Article
- Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms.Translational psychiatry · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Although there is considerable evidence for a strong genetic component to idiopathic autism, several genome-wide screens for susceptibility genes have been carried out with limited concordance of linked loci, reflecting numerous genes of weak effect and/or sample heterogeneity. In the current study, linkage analysis was carried out in a sample of 62 autism-affected relative pairs with more severe obsessive-compulsive behaviors, selected from a larger (n=115) set of autism-affected relative pairs as a means of reducing sample heterogeneity. Obsessive-compulsive behaviors were assessed using the Autism Diagnostic Interview-Revised (ADI-R). In the sample with more severe obsessive-compulsive behaviors, multipoint NPL scores above 2 were observed on chromosomes 1, 4, 5, 6, 10, 11 and 19, with the strongest evidence for linkage on chromosome 1 at the marker D1S1656, where the multipoint NPL score was 3.06, and the two-point NPL score was 3.21. In follow-up analyses, analyzing the subset of families (n=35) where the patients had the most severe obsessive-compulsive behaviors generated a multipoint NPL score of 2.76, and a two-point NPL score of 2.79, indicating that the bulk of evidence for linkage was derived from the families most severely affected with obsessive-compulsive behaviors. The data suggest that there is an autism susceptibility gene on chromosome 1 and provide further support for the presence of autism susceptibility genes on chromosomes 6 and 19.
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