SynthesisEnvironmental health perspectives2004
Prospective pregnancy study designs for assessing reproductive and developmental toxicants.
Synthesis in Environmental health perspectives, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed.
- Environmental factors in declining human fertility.Nature reviews. Endocrinology · 2022Review
- Feasibility of mail-based biospecimen collection in an online preconception cohort study.Frontiers in reproductive health · 2022Article
- Environmental hazards, social inequality, and fetal loss: Implications of live-birth bias for estimation of disparities in birth outcomes.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Reproductive outcomes associated with flame retardants among couples seeking fertility treatment: A paternal perspective.Environmental research · 2021Article
- Changes in Behavior with Increasing Pregnancy Attempt Time: A Prospective Cohort Study.Epidemiology (Cambridge, Mass.) · 2020Article
- Compliance with daily, home-based collection of urinary biospecimens in a prospective, preconception cohort.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
- Time-Varying Effects of Signs and Symptoms on Pregnancy Loss <20 Weeks: Findings from a Preconception Prospective Cohort Study.Paediatric and perinatal epidemiology · 2018Article
- Semen quality and pregnancy loss in a contemporary cohort of couples recruited before conception: data from the Longitudinal Investigation of Fertility and the Environment (LIFE) Study.Fertility and sterility · 2017Observational
- Transitions in pregnancy planning in women recruited for a large prospective cohort study.Human reproduction (Oxford, England) · 2017Article
- Fathers Matter: Why It's Time to Consider the Impact of Paternal Environmental Exposures on Children's Health.Current epidemiology reports · 2017Article
- Article
- Lifestyle and pregnancy loss in a contemporary cohort of women recruited before conception: The LIFE Study.Fertility and sterility · 2016Article
- The Home Observation of Periconceptional Exposures (HOPE) study, a prospective cohort: aims, design, recruitment and compliance.Environmental health : a global access science source · 2016Observational
- The National Children's Study: Recruitment Outcomes Using the Provider-Based Recruitment Approach.Pediatrics · 2016Article
- The National Children's Study: Recruitment Outcomes Using an Enhanced Household-Based Approach.Pediatrics · 2016Article
- Signs and symptoms associated with early pregnancy loss: findings from a population-based preconception cohort.Human reproduction (Oxford, England) · 2016Article
- Associations between urinary phthalate concentrations and semen quality parameters in a general population.Human reproduction (Oxford, England) · 2015Article
- Lessons from Prenatal Care Provider-Based Recruitment into the National Children's Study.Pediatric reports · 2015Article
- Impact of preconception enrollment on birth enrollment and timing of exposure assessment in the initial vanguard cohort of the U.S. National Children's Study.BMC medical research methodology · 2015Article
- Design and Conduct of an Internet-Based Preconception Cohort Study in North America: Pregnancy Study Online.Paediatric and perinatal epidemiology · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The determinants of successful human reproduction and development may act as early as periconceptionally, underscoring the need to capture exposures during these critical windows when assessing potential toxicants. To identify such toxicants, couples must be studied longitudinally prior to conception without regard to a couple's ability to ascertain a clinically recognized pregnancy. We examined the utility and feasibility of prospective pregnancy study designs by conducting a systematic review of the literature to summarize relevant information regarding the planning, implementation, and success of previously published prospective pregnancy studies. Information concerning design elements and participation was abstracted from 15 eligible studies (from a total of 20 identified studies) using a standardized form. The primary author of each study was contacted to review our summary of their work and obtain missing information. Our findings confirm the ability to recruit women/couples from diverse populations using a variety of recruitment strategies. Among the studies we reviewed, 4-97% of eligible individuals were successfully contacted, with enrollment rates ranging from 42 to 100%. Length of follow-up varied from 3 to 12 months. A high percentage of women provided urine (57-98%) and blood (86-91%) specimens and most male partners (94-100%) provided semen samples. These data support the feasibility of this design.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.