ArticleEnvironmental health perspectives2004
Correlation between blood ethylenethiourea and thyroid gland disorders among banana plantation workers in the Philippines.
Article in Environmental health perspectives, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Systematic review of human biomonitoring studies of ethylenethiourea, a urinary biomarker for exposure to dithiocarbamate fungicides.Environmental pollution (Barking, Essex : 1987) · 2022Pooled it
- Advances in the neurotoxicity of ecological pesticide maneb: mechanisms and implications for human health.Frontiers in public health · 2026Review
- Article
- Mechanistic Insights into Mancozeb-Induced Redox Imbalance and Structural Remodelling Affecting the Function of Human Red Blood Cells.Antioxidants (Basel, Switzerland) · 2025Article
- The Study of Environmental Exposure of Mothers and Infants Impacted by Large-Scale Agriculture (SEMILLA): Description of the Aims and Methods of a Community-Based Birth Cohort Study.Children (Basel, Switzerland) · 2024Article
- Association between pesticide exposure and thyroid function: analysis of Chinese and NHANES databases.Frontiers in public health · 2024Article
- Dithiocarbamates: Properties, Methodological Approaches and Challenges to Their Control.Toxics · 2023Review
- Exposure to common-use pesticides, manganese, lead, and thyroid function among pregnant women from the Infants' Environmental Health (ISA) study, Costa Rica.The Science of the total environment · 2022Article
- Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels.International journal of molecular sciences · 2021Review
- Endocrine-disrupting activity of mancozeb.Arhiv za farmaciju · 2021Article
- Coordination as Management Response to the Spread of a Global Plant Disease: A Case Study in a Major Philippine Banana Production Area.Frontiers in plant science · 2019Article
- Environmental and biological monitoring for the identification of main exposure determinants in vineyard mancozeb applicators.Journal of exposure science & environmental epidemiology · 2018Article
- Characterization of Pesticide Exposure in a Sample of Pregnant Women in Ecuador.Archives of environmental contamination and toxicology · 2016Article
- Assessing the impact of aerial pesticide spraying: mancozeb exposures among pregnant women living near banana plantations.Environmental health perspectives · 2014Article
- Aerial application of mancozeb and urinary ethylene thiourea (ETU) concentrations among pregnant women in Costa Rica: the Infants' Environmental Health Study (ISA).Environmental health perspectives · 2014Article
- Comparison of current-use pesticide and other toxicant urinary metabolite levels among pregnant women in the CHAMACOS cohort and NHANES.Environmental health perspectives · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ethylenebisdithiocarbamates (EBDCs) are metabolized into ethylenethiourea (ETU), a possible human carcinogen and an antithyroid compound. In this study our goal was to correlate ETU levels with the incidence of thyroid gland disorders among banana plantation workers exposed to EBDC. We randomly selected 57 directly exposed workers and 31 indirectly exposed workers from four banana plantations and 43 workers from an organic farm; all subjects underwent complete medical examinations and laboratory tests. Results showed a higher mean thyroid-stimulating hormone measurement among exposed workers compared with the control group, although the levels were well within normal range. Nine of the exposed farmers had abnormal thyroid ultrasound findings, consisting mostly of solitary nodules, compared with three among the control group. Analysis of variance showed significantly different blood ETU levels among the directly exposed, indirectly exposed, and control groups (p < 0.001), but ETU levels in urine were not significantly different (p = 0.10). Environmental ETU levels were below the U.S. Environmental Protection Agency remediation levels. Among farmers with solitary thyroid nodules, we found a very good direct correlation between the size of the nodule and blood ETU level. In this study we showed that blood ETU is a more reliable biomarker for EBDC exposure than urinary ETU; therefore, the determination of blood ETU should be part of medical surveillance efforts among workers exposed to EBDC to detect occurrences of thyroid gland disorders.
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