ArticleEnvironmental health perspectives2004
Relationship of serum TCDD concentrations and age at exposure of female residents of Seveso, Italy.
Article in Environmental health perspectives, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 86 citations in OpenAlex.
- Dioxin exposure associated with fecundability and infertility in mothers and daughters of Seveso, Italy.Human reproduction (Oxford, England) · 2021Article
- Transgenerational disease specific epigenetic sperm biomarkers after ancestral exposure to dioxin.Environmental research · 2021Article
- Age at menarche in Seveso daughters exposed in utero to 2,3,7,8-tetrachlorodibenzo-p-dioxin.Environmental epidemiology (Philadelphia, Pa.) · 2020Article
- Prenatal dioxin exposure and thyroid hormone levels in the Seveso second generation study.Environmental research · 2020Article
- Prenatal dioxin exposure and glucose metabolism in the Seveso Second Generation study.Environment international · 2020Article
- In utero dioxin exposure and cardiometabolic risk in the Seveso Second Generation Study.International journal of obesity (2005) · 2019Article
- Application of qualitative and quantitative uncertainty assessment tools in developing ranges of plausible toxicity values for 2,3,7,8-tetrachlorodibenzo-p-dioxin.Journal of applied toxicology : JAT · 2019Article
- Prenatal dioxin exposure and neuropsychological functioning in the Seveso Second Generation Health Study.International journal of hygiene and environmental health · 2019Article
- The 2nd to 4th digit length ratio (2D:4D) among children of Seveso women exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.Early human development · 2019Article
- The Seveso accident: A look at 40 years of health research and beyond.Environment international · 2018Review
- AHR gene-dioxin interactions and birthweight in the Seveso Second Generation Health Study.International journal of epidemiology · 2018Article
- Risk for animal and human health related to the presence of dioxins and dioxin-like PCBs in feed and food.EFSA journal. European Food Safety Authority · 2018Article
- Neurocognitive and physical functioning in the Seveso Women's Health Study.Environmental research · 2018Article
- Prenatal exposure to TCDD and atopic conditions in the Seveso second generation: a prospective cohort study.Environmental health : a global access science source · 2018Article
- Adolescents exposed to the World Trade Center collapse have elevated serum dioxin and furan concentrations more than 12years later.Environment international · 2018Article
- Genistein PreventsCurrent developments in nutrition · 2017Article
- Chronic Exposure to Low Doses of Dioxin Promotes Liver Fibrosis Development in the C57BL/6J Diet-Induced Obesity Mouse Model.Environmental health perspectives · 2017Article
- Dioxin induction of transgenerational inheritance of disease in zebrafish.Molecular and cellular endocrinology · 2014Review
- Serum TCDD and TEQ concentrations among Seveso women, 20 years after the explosion.Journal of exposure science & environmental epidemiology · 2014Article
- Serum dioxin concentrations and thyroid hormone levels in the Seveso Women's Health Study.American journal of epidemiology · 2014Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
In 1976, a chemical plant explosion near Seveso, Italy, resulted in the highest known exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in residential populations. In 1996, we initiated the Seveso Women's Health Study (SWHS), a historical cohort study of females who were 40 years old at the time of explosion and residents of the most heavily contaminated areas, zones A and B. Serum samples collected near the time of the explosion were analyzed for TCDD. We also analyzed pooled serum samples collected in 1976 from females who resided in zone non-ABR, the "unexposed" zone, to assess concurrent background exposures to other dioxins, furans, and coplanar polychlorinated biphenyls (PCBs). The median lipid-adjusted TCDD level for residents of zones A and B combined was 56 ppt (range = 2.5-56,000 ppt). Zone A residents had 5-fold higher TCDD levels (n = 67, median = 272 ppt) than did zone B residents (n = 814, median = 47 ppt). The youngest children had the highest TCDD levels, which decreased with age at explosion until approximately 13 years of age and were constant thereafter. Therefore, children living in zones A and B received a disproportionately higher exposure to TCDD as a result of the explosion. Zone of residence and age were the strongest predictors of TCDD level. Chloracne, nearby animal mortality, location (outdoors vs. indoors) at the time of explosion, and consumption of homegrown food were also related to serum TCDD levels. The serum pools from zone non-ABR residents had an average TCDD concentration of 20.2 ppt, and average total toxic equivalent (TEQ) concentration of 100.4 ppt. Therefore, background exposure to dioxins, furans, and PCBs unrelated to the explosion may have been substantial. As a consequence, previous SWHS studies that considered only TCDD exposure may have underestimated health effects due to total TEQ concentrations.
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