ArticleDevelopmental biology2004
HB-EGF directs stromal cell polyploidy and decidualization via cyclin D3 during implantation.
Article in Developmental biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 115 citations in OpenAlex.
- MMP3 mediates E2-induced bovine endometrial cell proliferation by releasing HB-EGF.The Journal of reproduction and development · 2025Article
- Alternative Splicing in Embryo Implantation.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2025Review
- The Multiple Functions of HB-EGF in Female Reproduction and Related Cancer: Molecular Mechanisms and Targeting Strategies.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- A Novel Method to Repair Thin Endometrium and Restore Fertility Based on Menstruation-Derived Stem Cell.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- MiR-135a-5p regulates window of implantation by suppressing pinopodes development and decidualization of endometrial stromal cells.Journal of assisted reproduction and genetics · 2024Article
- A Potential Role of CD82/KAI1 during Uterine Decidualization in Mice.Current issues in molecular biology · 2024Article
- Tryptophan in the mouse diet is essential for embryo implantation and decidualization.Frontiers in endocrinology · 2024Article
- Article
- Uterine deficiency of Dnmt3b impairs decidualization and causes consequent embryo implantation defects.Cell biology and toxicology · 2023Article
- Distinguish Characters of Luminal and Glandular Epithelium from Mouse Uterus Using a Novel Enzyme-Based Separation Method.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Progress on the Role of Estrogen and Progesterone Signaling in Mouse Embryo Implantation and Decidualization.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Rhythm of the First Language: Dynamics of Extracellular Vesicle-Based Embryo-Maternal Communication in the Pre-Implantation Microenvironment.International journal of molecular sciences · 2023Article
- Follistatin is a crucial chemoattractant for mouse decidualized endometrial stromal cell migration by JNK signalling.Journal of cellular and molecular medicine · 2023Article
- The regulation and function of acetylated high-mobility group box 1 during implantation and decidualization.Frontiers in immunology · 2023Article
- Shp2 in uterine stromal cells critically regulates on time embryo implantation and stromal decidualization by multiple pathways during early pregnancy.PLoS genetics · 2022Article
- TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway.Experimental & molecular medicine · 2021Article
- Exposure to butylated hydroxytoluene compromises endometrial decidualization during early pregnancy.Environmental science and pollution research international · 2021Article
- HB-EGF Ameliorates Oxidative Stress-Mediated Uterine Decidualization Damage.Oxidative medicine and cellular longevity · 2019Article
- Homeobox genes for embryo implantation: From mouse to human.Animal models and experimental medicine · 2018Review
- Decidualisation and placentation defects are a major cause of age-related reproductive decline.Nature communications · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Stromal cell polyploidy is a unique phenomenon that occurs during uterine decidualization following embryo implantation, although the developmental mechanism still remains elusive. The general consensus is that the aberrant expression and altered functional activity of cell cycle regulatory molecules at two particular checkpoints G1 to S and G2 to M in the cell cycle play an important role in the development of cellular polyploidy. Despite the compelling evidence of intrinsic cell cycle alteration, it has been implicated that the development of cellular polyploidy may be controlled by specific actions of extracellular growth regulators. Here we show a novel role for heparin-binding EGF-like growth factor (HB-EGF) in the developmental process of stromal cell polyploidy in mice. HB-EGF, which is one of the earliest known molecular mediators of implantation in mice and humans, promotes stromal cell polyploidy via upregulation of cyclin D3. Adenoviral delivery of antisense cyclin D3 attenuates cyclin D3 expression and abrogates HB-EGF-induced stromal cell polyploidy in vitro and in vivo. Collectively, the results demonstrate that the regulation of stromal cell polyploidy and decidualization induced by HB-EGF depend on cyclin D3 induction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.