ArticleWorld journal of gastroenterology2004
Effects of cytokines on carbon tetrachloride-induced hepatic fibrogenesis in rats.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 61 citations in OpenAlex.
- Selenium Nanoparticles Functionalized with Glycosmis pentaphylla Extract Attenuate Hepatic Fibrosis Through Modulation of Oxidative Stress and Anti-Inflammatory Responses.Applied biochemistry and biotechnology · 2026Article
- Oxidative Stress in Liver Pathophysiology and Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Pharmacological properties of baicalin on liver diseases: a narrative review.Pharmacological reports : PR · 2021Review
- Methanol extract of Muntingia calabura leaves attenuates CClPharmaceutical biology · 2019Article
- Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol mediated liver fibrosis in mice.Lipids in health and disease · 2013Article
- Hepatoprotective activity of the ethanol extract of Sarcopyramis Nepalensis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2012Article
- Intestinal and plasma VEGF levels in cirrhosis: the role of portal pressure.Journal of cellular and molecular medicine · 2012Article
- Intravenous injection of mesenchymal stem cells is effective in treating liver fibrosis.World journal of gastroenterology · 2012Article
- Resveratrol regulates antioxidant status, inhibits cytokine expression and restricts apoptosis in carbon tetrachloride induced rat hepatic injury.Oxidative medicine and cellular longevity · 2011Article
- Correlation between anti-fibrotic effect of baicalin and serum cytokines in rat hepatic fibrosis.World journal of gastroenterology · 2009Article
- Inhibitory effects of saikosaponin-d on CCl4-induced hepatic fibrogenesis in rats.World journal of gastroenterology · 2007Article
- Relationship between transforming growth factor beta1 and anti-fibrotic effect of interleukin-10.World journal of gastroenterology · 2006Article
- Effects of interleukin-10 on activation and apoptosis of hepatic stellate cells in fibrotic rat liver.World journal of gastroenterology · 2006Article
- Interleukin-10 and chronic liver disease.World journal of gastroenterology · 2006Review
- Expression and location of Smad2, 4 mRNAs during and after liver fibrogenesis of rats.World journal of gastroenterology · 2006Article
- Therapeutic effect of interleukin-10 on CCl4-induced hepatic fibrosis in rats.World journal of gastroenterology · 2006Article
- Hepatoprotective effects of brown algaeAvicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo observe the possible effects of transforming growth factor (TGF) beta(1), interleukin (IL)-6, tumor-necrosis factor (TNF) alpha and IL-10 on experimental rat hepatic fibrosis.
methodsOne hundred SD rats were divided randomly into the three groups. Control group received intraperitoneal injection of saline (2 ml/kg(-1)), twice a week. Fibrogenesis group was injected intraperitoneally with 50% carbon tetrachloride (CCl(4)) (2 ml/kg(-1)) twice a week. Fibrosis-intervention group was given IL-10 at a dose of 4 microg/kg(-1) 20 minutes before CCl(4) administration from the third week. At the fifth, seventh, and ninth weeks, 7 to 10 rats in each group were sacrificed to collect serum. Levels of TGF-beta(1), TNF-alpha, IL-6 and IL-10 were determined by enzyme-linked immunosorbent assay (ELISA). The liver tissues were taken for routine histological examination.
resultsHepatic fibrosis was developed with the injection of CCl(4). Values of the circulating TGFbeta(1), TNFalpha, IL-6 and IL-10 in the control group were 25.49+/-5.56 ng/L(-1), 15.18+/-3.83 ng/L(-1), 63.64+/-13.03 ng/L(-1) and 132.90+/-12.13 ng/L(-1), respectively. Their levels in the CCl(4)-intoxication group were 31.13+/-6.41 ng/L(-1), 18.91+/-5.31 ng/L(-1), 89.08+/-25.39 ng/L(-1) and 57.63+/-18.88 ng/L(-1), respectively, and those in the IL-10-intervention group were 26.11+/-5.32 ng/L(-1), 13.99+/-1.86 ng/L(-1), 74.71+/-21.15 ng/L(-1) and 88.19+/-20.81 ng/L(-1), respectively. A gradual increase was observed in the levels of TGFbeta(1), TNFalpha and IL-6 during hepatic fibrogenesis. These changes were partially reversed by simultaneous administration of IL-10. The histological parameters, characterized by CCl(4)-intoxification, also seemed to be improved with IL-10 treatment, the collagen production was reduced at the ninth week and the histological activity index was decreased from 7.9+/-1.2 to 4.7+/-0.9.
conclusionTGFbeta(1), TNFalpha and IL-6 may play important roles during CCl(4)-induced hepatic fibrogenesis, and IL-10 may counterbalance their effects.
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