Trial reportJournal of medical virology2004
Presence of specific viruses in the middle ear fluids and respiratory secretions of young children with acute otitis media.
Trial report in Journal of medical virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- RSV-associated acute otitis media in children under five years old: a systematic review and meta-analysis.Journal of global health · 2026Pooled it
- Shorter versus longer antibiotic therapy for children with acute otitis media: A systematic review.European journal of pediatrics · 2026Pooled it
- The Burden of Respiratory Syncytial Virus in Children With Acute Otitis Media: A Systematic Review and Meta-Analysis.Influenza and other respiratory viruses · 2026Pooled it
- Human bocavirus in the nasopharynx of otitis-prone children.International journal of pediatric otorhinolaryngology · 2012Trial
- Acute otitis media and respiratory viruses.European journal of pediatrics · 2007Trial
- Case-control study of relationship of infection by respiratory viruses with acute otitis media in Chinese children.Heliyon · 2023Article
- The Roles of NOD-like Receptors in Innate Immunity in Otitis Media.International journal of molecular sciences · 2022Review
- Predominant Bacterial and Viral Otopathogens Identified Within the Respiratory Tract and Middle Ear of Urban Australian Children Experiencing Otitis Media Are Diversely Distributed.Frontiers in cellular and infection microbiology · 2022Article
- Translating Recent Microbiome Insights in Otitis Media into Probiotic Strategies.Clinical microbiology reviews · 2019Review
- Improved Detection of Respiratory Pathogens by Use of High-Quality Sputum with TaqMan Array Card Technology.Journal of clinical microbiology · 2017Article
- Modelling estimates of the burden of respiratory syncytial virus infection in children in the UK.BMJ open · 2016Observational
- Detection of respiratory pathogens in pediatric acute otitis media by PCR and comparison of findings in the middle ear and nasopharynx.Diagnostic microbiology and infectious disease · 2016Article
- Evidence and evidence gaps in the treatment of Eustachian tube dysfunction and otitis media.GMS current topics in otorhinolaryngology, head and neck surgery · 2016Review
- Importance of viruses in acute otitis media.Current opinion in pediatrics · 2015Review
- Role of Human Bocavirus in Upper Respiratory Tract Infections and Acute Otitis Media.Journal of the Pediatric Infectious Diseases Society · 2014Article
- Microbial profiling does not differentiate between childhood recurrent acute otitis media and chronic otitis media with effusion.International journal of pediatric otorhinolaryngology · 2013Article
- Bacterial and viral interactions within the nasopharynx contribute to the risk of acute otitis media.The Journal of infection · 2013Article
- Viral-bacterial interactions in acute otitis media.Current allergy and asthma reports · 2012Review
- Presence of viral nucleic acids in the middle ear: acute otitis media pathogen or bystander?The Pediatric infectious disease journal · 2012Review
- Viral interference induced by live attenuated virus vaccine (OPV) can prevent otitis media.Vaccine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of the study was to investigate the presence of different viruses in middle ear fluids and nasopharyngeal aspirates in young children with acute otitis media. Two cohorts of children (N = 329 and 611) were followed from 2 to 24 months of age in Finland in two prospective studies (Finnish Otitis Media Cohort Study and Finnish Otitis Media Vaccine Trial). During the study period, nasopharyngeal and middle ear fluid specimens for each acute otitis media event were examined for eight (Cohort Study) or ten (Vaccine Trial) common respiratory viruses; adenoviruses, influenza viruses A and B, parainfluenza viruses 1, 2, and 3, respiratory syncytial virus (RSV), enteroviruses, parechoviruses, and rhinoviruses. Picornaviruses (rhinoviruses, enteroviruses, and parechoviruses) were determined by reverse transcription PCR while antigen detection was used for the other viruses. A virus was present in either nasopharyngeal or middle ear specimen in 54% of events in the first cohort and in 67% of events in the second. Rhinoviruses formed the most common virus group detected (41-32%), followed by enteroviruses (25%, sought in the second cohort only) and respiratory syncytial virus (RSV) (10%). All the other viruses represented jointly 8-10% of the events. In conclusion, using the methods described in this study, a specific virus infection was diagnosed in two thirds of all acute otitis media events in young children. Picornavirus RNA was detected in association with more than a half of all acute otitis media events. The use of PCR-based methods for the other respiratory viruses might have increased further the overall virus detection rate in acute otitis media.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.