ArticleThe American journal of pathology2004
Antigen transport into Peyer's patches: increased uptake by constant numbers of M cells.
Article in The American journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Influence of Alcohol on the Intestinal Immune System.Alcohol research : current reviews · 2025Pooled it
- Increased number of intestinal villous M cells in levamisole -pretreated weaned pigs experimentally infected with F4ac⁺ enterotoxigenic Escherichia coli strain.European journal of histochemistry : EJH · 2010Trial
- Micro- and Nanoplastics as Emerging Drivers of Liver Injury: Exposure, Evidence, and Mechanisms.International journal of molecular sciences · 2026Review
- Morphological Characterization of Intrafollicular Epithelial Bodies (IFEBs) in Rabbit Peyer's Patches.International journal of molecular sciences · 2025Article
- Gut-liver axis: Recent concepts in pathophysiology in alcohol-associated liver disease.Hepatology (Baltimore, Md.) · 2024Review
- B and T Cell Immunity in Tissues and Across the Ages.Vaccines · 2021Review
- A Perspective Of Intestinal Immune-Microbiome Interactions In Alcohol-Associated Liver Disease.International journal of biological sciences · 2021Review
- Milk Processing Affects Structure, Bioavailability and Immunogenicity of β-lactoglobulin.Foods (Basel, Switzerland) · 2020Review
- Activated Peyer's patch B cells sample antigen directly from M cells in the subepithelial dome.Nature communications · 2019Article
- M Cells: Intelligent Engineering of Mucosal Immune Surveillance.Frontiers in immunology · 2019Review
- The challenges of oral drug delivery via nanocarriers.Drug delivery · 2018Review
- Diet induced changes in the microbiota and cell composition of rabbit gut associated lymphoid tissue (GALT).Scientific reports · 2018Article
- Oral Vaccine Delivery for Intestinal Immunity-Biological Basis, Barriers, Delivery System, and M Cell Targeting.Polymers · 2018Review
- Peyer's patches: organizing B-cell responses at the intestinal frontier.Immunological reviews · 2016Review
- Survey of Omp19 immunogenicity against Brucella abortus and Brucella melitensis: influence of nanoparticulation versus traditional immunization.Veterinary research communications · 2015Article
- Linkage between genotype and immunological phenotype in Crohn's disease.Annals of translational medicine · 2015Article
- Proliferation and apoptosis of Peyer's patches and its lymphocytes in experimental terminal ileitis.International journal of clinical and experimental pathology · 2014Article
- Working out mechanisms of controlled/physiologic inflammation in the GI tract.Immunologic research · 2012Review
- Convergent and divergent development among M cell lineages in mouse mucosal epithelium.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Campylobacter jejuni induces transcytosis of commensal bacteria across the intestinal epithelium through M-like cells.Gut pathogens · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Membranous (M) cells are specialized epithelial cells of the Peyer's patches that sample antigens from the gut lumen, thereby enabling the host to respond immunologically. Recent studies suggest that this transport can be up-regulated within hours by de novo formation of M cells from enterocytes. To test this hypothesis, we used an in vivo model and induced the transcytosis of tracers in Peyer's patches by application of Streptococcus pneumoniae R36a into the gut lumen. Using cell-type-specific markers, we quantified M cells in the Peyer's patch domes, lymphocytes associated with M cells, and the transport rate for experimentally applied microbeads after 3 hours of exposure to R36a. The transport of latex microbeads was significantly increased by +131% in the R36a-treated patches as compared to buffer controls (P < 0.001). While in controls, each M cell was associated with 2.05 +/- 0.64 lymphocytes, a significant increase (+55.1%; P < 0.001) was determined in the R36a-treated patches. However, no statistical difference was detected in the percentage of M cells in the dome epithelia (46.0 +/- 4.6% versus 45.5 +/- 3.8%). It is concluded that bacteria-induced up-regulation of particle transport in Peyer's patch domes is due to an increased transport rate of the M cells, but not to a de novo formation of M cells. The data support the hypothesis that M cells represent a separate cell lineage that does not derive from enterocytes on the domes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.