ArticleBiophysical journal2004
Measuring hearing organ vibration patterns with confocal microscopy and optical flow.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- TRPA1 activation in non-sensory supporting cells contributes to regulation of cochlear sensitivity after acoustic trauma.Nature communications · 2023Article
- Regulation of Endothelial Nitric Oxide Synthase in the Reticular Lamina of the Organ of Corti by a Nitric Oxide Donor.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021Article
- Static length changes of cochlear outer hair cells can tune low-frequency hearing.PLoS computational biology · 2018Article
- Effects of salicylate on sound-evoked outer hair cell stereocilia deflections.Pflugers Archiv : European journal of physiology · 2015Article
- Vibration of the organ of Corti within the cochlear apex in mice.Journal of neurophysiology · 2014Article
- Instrumentation for studies of cochlear mechanics: from von Békésy forward.Hearing research · 2012Review
- Sound-induced length changes in outer hair cell stereocilia.Nature communications · 2012Article
- The endocochlear potential alters cochlear micromechanics.Biophysical journal · 2011Article
- Membrane cholesterol modulates cochlear electromechanics.Pflugers Archiv : European journal of physiology · 2011Article
- Measurement of instantaneous velocity vectors of organelle transport: mitochondrial transport and bioenergetics in hippocampal neurons.Biophysical journal · 2008Article
- Medial olivocochlear efferent inhibition of basilar-membrane responses to clicks: evidence for two modes of cochlear mechanical excitation.The Journal of the Acoustical Society of America · 2008Article
- Sound-evoked radial strain in the hearing organ.Biophysical journal · 2007Article
- Nanomechanics of the subtectorial space caused by electromechanics of cochlear outer hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Imaging hair cell transduction at the speed of sound: dynamic behavior of mammalian stereocilia.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Vibration pattern of the organ of Corti up to 50 kHz: evidence for resonant electromechanical force.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new method for visualizing vibrating structures is described. The system provides a means to capture very fast repeating events by relatively minor modifications to a standard confocal microscope. An acousto-optic modulator was inserted in the beam path, generating brief pulses of laser light. Images were formed by summing consecutive frames until every pixel of the resulting image had been exposed to a laser pulse. Images were analyzed using a new method for optical flow computation; it was validated through introducing artificial displacements in confocal images. Displacements in the range of 0.8 to 4 pixels were measured with 5% error or better. The lower limit for reliable motion detection was 20% of the pixel size. These methods were used for investigating the motion pattern of the vibrating hearing organ. In contrast to standard theory, we show that the organ of Corti possesses several degrees of freedom during sound-evoked vibration. Outer hair cells showed motion indicative of deformation. After acoustic overstimulation, supporting cells contracted. This slowly developing structural change was visualized during simultaneous intense sound stimulation and its speed measured with the optical flow technique.
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Registered trials
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