ArticleBiophysical journal2004
Polymorphism of Ca2+ sparks evoked from in-focus Ca2+ release units in cardiac myocytes.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- A Stochastic Spatiotemporal Model of Rat Ventricular Myocyte Calcium Dynamics Demonstrated Necessary Features for Calcium Wave Propagation.Membranes · 2021Article
- Control of sarcoplasmic reticulum Ca2+ release by stochastic RyR gating within a 3D model of the cardiac dyad and importance of induction decay for CICR termination.Biophysical journal · 2013Article
- Parameter sensitivity analysis of stochastic models provides insights into cardiac calcium sparks.Biophysical journal · 2013Article
- Abnormal Ca2+ spark/STOC coupling in cerebral artery smooth muscle cells of obese type 2 diabetic mice.PloS one · 2013Article
- Properties of Ca2+ sparks revealed by four-dimensional confocal imaging of cardiac muscle.The Journal of general physiology · 2012Article
- Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles.Journal of molecular and cellular cardiology · 2012Review
- Quarky calcium release in the heart.Circulation research · 2011Article
- Theory and applications of geometric scaling of localized calcium release events.American journal of physiology. Cell physiology · 2010Article
- Deciphering ryanodine receptor array operation in cardiac myocytes.The Journal of general physiology · 2010Article
- Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Dynamic interreceptor coupling contributes to the consistent open duration of ryanodine receptors.Biophysical journal · 2009Article
- Indirect coupling between Cav1.2 channels and ryanodine receptors to generate Ca2+ sparks in murine arterial smooth muscle cells.The Journal of physiology · 2007Article
- Excitation-contraction coupling and mitochondrial energetics.Basic research in cardiology · 2007Review
- Multidimensional detection and analysis of Ca2+ sparks in cardiac myocytes.Biophysical journal · 2007Article
- A 3D Monte Carlo analysis of the role of dyadic space geometry in spark generation.Biophysical journal · 2006Article
- Using total fluorescence increase (signal mass) to determine the Ca2+ current underlying localized Ca2+ events.The Journal of general physiology · 2004Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Ca2+ sparks are the elementary release events in many types of cells. Here we present a morphometric analysis of Ca2+ sparks (i.e., amplitude and kinetic parameters) using an approach that minimizes the confounding factor of the detection of out-of-focus events. By activation and visualization of Ca2+ sparks from Ca2+ release units under loose-seal patch-clamp conditions, we found that the amplitude and rising rate of in-focus sparks exhibited a broad modal distribution, whereas spark rise time and spatial width appeared to be stereotyped. Spark morphometrics were constant irrespective of the latency of spark production and the time-dependent L-type Ca2+ channel activation. Polymorphism of Ca2+ sparks in terms of variable amplitude and rising rate was evident for events from the same release units, and intra- and interrelease unit variability contributed equally to the overall variability. The rising rate, a reporter of the underlying Ca2+ release flux, displayed a strong positive correlation with spark amplitude, but a negative correlation with spark rise time, an index of Ca2+ release duration. On the basis of Ca2+ spark morphometrics measured here, we suggested a model in which cohorts of variable number of ryanodine receptors are activated in the genesis of Ca2+ sparks, and the ensuing negative feedback overrides the regenerative Ca2+-induced Ca2+ release to extinguish the ongoing Ca2+ spark.
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