ArticleBiophysical journal2004
Self-organization of polarized cell signaling via autocrine circuits: computational model analysis.
Article in Biophysical journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Interlinked switch circuits of biological intelligence.Trends in biochemical sciences · 2024Article
- A systems perspective of heterocellular signaling.Essays in biochemistry · 2018Review
- Theoretical method for evaluation of therapeutic effects and adverse effects of epidermal growth factor receptor tyrosine kinase inhibitors in clinical treatment.Medical oncology (Northwood, London, England) · 2017Article
- Relaxation oscillations and hierarchy of feedbacks in MAPK signaling.Scientific reports · 2017Article
- Mathematical modeling of eukaryotic cell migration: insights beyond experiments.Annual review of cell and developmental biology · 2013Review
- An investigation of spatial signal transduction in cellular networks.BMC systems biology · 2012Article
- Mathematical analysis of steady-state solutions in compartment and continuum models of cell polarization.Mathematical biosciences and engineering : MBE · 2011Article
- A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.PLoS computational biology · 2011Review
- Modeling robustness tradeoffs in yeast cell polarization induced by spatial gradients.PloS one · 2008Article
- Coarse-grained molecular simulation of diffusion and reaction kinetics in a crowded virtual cytoplasm.Biophysical journal · 2008Article
- Wave-pinning and cell polarity from a bistable reaction-diffusion system.Biophysical journal · 2008Article
- Simulating non-small cell lung cancer with a multiscale agent-based model.Theoretical biology & medical modelling · 2007Article
- Multiple-state reactions between the epidermal growth factor receptor and Grb2 as observed by using single-molecule analysis.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Phosphoinositides and Rho proteins spatially regulate actin polymerization to initiate and maintain directed movement in a one-dimensional model of a motile cell.Biophysical journal · 2007Article
- Cell-signalling dynamics in time and space.Nature reviews. Molecular cell biology · 2006Review
- Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway.The Biochemical journal · 2005Review
- Cholesterol dictates the freedom of EGF receptors and HER2 in the plane of the membrane.Biophysical journal · 2005Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Recent studies have suggested that autocrine signaling through epidermal growth factor receptor (EGFR) might be involved in generating or maintaining an intrinsic polarity in tissue cells, possibly via spatial localization of EGFR-mediated signaling. The difficulty of experimental investigation of autocrine signaling makes especially valuable an application of computational modeling for critical hypotheses about the dynamic operation of the underlying signaling circuits, both intracellular and extracellular. Toward this end, we develop and analyze here a spatially distributed dynamic computational model of autocrine EGFR signaling. Under certain conditions, the model spontaneously evolves into a state wherein sustained signaling is spatially localized on smaller than cell dimension, conferring a polarity to the otherwise nonpolar model cell. Conditions of a sufficiently large rate of autocrine EGFR ligand release and of a sufficiently small exogenous ligand concentration are qualitatively consistent with experimental observations of EGFR-mediated migration. Thus, computational analysis supports the concept that autocrine EGFR signaling circuits could play a role in helping generate and/or maintain an intrinsic cell spatial polarity, possibly related to migration as well as tissue organization. We additionally offer particular suggestions for critical nodes in the EGFR signaling circuits governing this self-organization capability.
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