ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2004
Sensorimotor gating deficits in transgenic mice expressing a constitutively active form of Gs alpha.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Possible role of the dopamine D1 receptor in the sensorimotor gating deficits induced by high-fat diet.Psychopharmacology · 2015Article
- Animal Models of Psychosis: Current State and Future Directions.Current behavioral neuroscience reports · 2014Article
- Critical role of nitric oxide in the modulation of prepulse inhibition in Swiss mice.Psychopharmacology · 2014Article
- McCune-Albright syndrome and the extraskeletal manifestations of fibrous dysplasia.Orphanet journal of rare diseases · 2012Review
- Realistic expectations of prepulse inhibition in translational models for schizophrenia research.Psychopharmacology · 2008Review
- Nicotine withdrawal disrupts both foreground and background contextual fear conditioning but not pre-pulse inhibition of the acoustic startle response in C57BL/6 mice.Behavioural brain research · 2008Article
- A novel rat strain with enhanced sensitivity to the effects of dopamine agonists on startle gating.Pharmacology, biochemistry, and behavior · 2008Article
- In vitro and in vivo demonstration of risperidone implants in mice.Schizophrenia research · 2008Article
- Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2007Article
- Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: relationship to clinical symptomatology and psychophysical olfactory performance.Schizophrenia research · 2007Article
- Pharmacokinetic and behavioral characterization of a long-term antipsychotic delivery system in rodents and rabbits.Psychopharmacology · 2007Article
- Rolipram: a specific phosphodiesterase 4 inhibitor with potential antipsychotic activity.Neuroscience · 2007Article
- Mice expressing constitutively active Gsalpha exhibit stimulus encoding deficits similar to those observed in schizophrenia patients.Neuroscience · 2006Article
- Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets.CNS & neurological disorders drug targets · 2006Review
- Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Activation of a nitric-oxide-sensitive cAMP pathway with phencyclidine: elevated hippocampal cAMP levels are temporally associated with deficits in prepulse inhibition.Psychopharmacology · 2005Article
- Chronically increased Gsalpha signaling disrupts associative and spatial learning.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Schizophrenia is a complex disorder characterized by wide-ranging cognitive impairments, including deficits in learning as well as sensory gating. The causes of schizophrenia are unknown, but alterations in intracellular G-protein signaling pathways are among the molecular changes documented in patients with schizophrenia. Using the CaMKIIalpha promoter to drive expression in neurons within the forebrain, we have developed transgenic mice that express a constitutively active form of G(s)alpha (G(s)alpha(*)), the G protein that couples receptors such as the D(1) and D(5) dopamine receptors to adenylyl cyclase. We have also generated mice in which the CaMKIIalpha promoter drives expression of a dominant-negative form of protein kinase A, R(AB). Here, we examine startle responses and prepulse inhibition of the startle reflex (PPI) in these G(s)alpha(*) and R(AB) transgenic mice. G(s)alpha(*) transgenic mice exhibited selective deficits in PPI, without exhibiting alterations in the startle response, whereas no deficit in startle or PPI was found in the R(AB) transgenic mice. Thus, overstimulation of the cAMP/PKA pathway disrupts PPI, but the cAMP/PKA pathway may not be essential for sensorimotor gating. G(s)alpha(*) transgenic mice may provide an animal model of certain endophenotypes of schizophrenia, because of the similarities between them and patients with schizophrenia in G-protein function, hippocampus-dependent learning, and sensorimotor gating.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.