ArticleThorax2004
Low birth weight for gestation and airway function in infancy: exploring the fetal origins hypothesis.
Article in Thorax, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 105 citations in OpenAlex.
- Vitamin A supplementation in extremely low-birth-weight infants: subgroup analysis in small-for-gestational-age infants.American journal of perinatology · 2013Trial
- The Impact of Small-for-Gestational-Age on Pulmonary Function in Infancy, a Retrospective Cohort Study.Pediatric pulmonology · 2026Article
- Occupational psychosocial stressors and ergonomic strain during pregnancy and sex-specific risk of childhood asthma.International archives of occupational and environmental health · 2025Article
- Respiratory distress syndrome and bronchopulmonary dysplasia after fetal growth restriction: Lessons from a natural experiment in identical twins.EClinicalMedicine · 2021Article
- Low lung function in the developing world is analogous to stunting: a review of the evidence.Wellcome open research · 2020Article
- Intrauterine growth restriction decreases NF-κB signaling in fetal pulmonary artery endothelial cells of fetal sheep.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Nutrition and Lung Growth.Nutrients · 2018Review
- Liraglutide Enhances the Activity of the ACE-2/Ang(1-7)/Mas Receptor Pathway in Lungs of Male Pups from Food-Restricted Mothers and Prevents the Reduction of SP-A.International journal of endocrinology · 2018Article
- Neonatal and Long-Term Consequences of Fetal Growth Restriction.Current pediatric reviews · 2018Review
- Raised-Volume Forced Expiratory Flow-Volume Curve in Healthy Taiwanese Infants.Scientific reports · 2017Article
- Article
- Pulmonary function in infants with swallowing dysfunction.PloS one · 2015Article
- Epigenetics of hyper-responsiveness to allergen challenge following intrauterine growth retardation rat.Respiratory research · 2014Article
- Impact of ethnicity and extreme prematurity on infant pulmonary function.Pediatric pulmonology · 2014Observational
- Maternal protein restriction alters VEGF signaling and decreases pulmonary alveolar in fetal rats.International journal of clinical and experimental pathology · 2014Article
- Epigenomics and allergic disease.Epigenomics · 2013Review
- Predictors for asthma at age 7 years for low-income children enrolled in the Childhood Asthma Prevention Study.The Journal of pediatrics · 2013Article
- Fetal growth and risk of childhood asthma and allergic disease.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Review
- The use of ethnically specific norms for ventilatory function in African-American and white populations.International journal of epidemiology · 2012Article
- Intrauterine growth restriction decreases pulmonary alveolar and vessel growth and causes pulmonary artery endothelial cell dysfunction in vitro in fetal sheep.American journal of physiology. Lung cellular and molecular physiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPoor fetal growth has been associated with impaired airway function in adult life, but evidence linking birth weight and airway function in early childhood is sparse. We examined the hypothesis that low birth weight for gestation is associated with impaired airway function shortly after birth and that this is independent of impaired postnatal somatic growth.
methodsAirway function was measured using the raised volume technique in healthy white infants of low (< or =10th centile) or appropriate (> or =20th centile) birth weight for gestation and was expressed as forced expiratory volume in 0.4 s (FEV0.4), forced vital capacity (FVC), and the maximal expired flow at 25% of forced vital capacity (MEF25). Infant length and weight, maternal height and weight, maternal report of smoking prenatally and postnatally, and parental occupation were recorded.
resultsMothers of low birth weight for gestation infants (n=98) were lighter, shorter, and more likely to smoke and have partners in manual occupations. At 6 weeks their infants remained lighter and shorter than those of appropriate birth weight (n=136). FEV0.4, FVC, and MEF25 were reduced in infants of low birth weight for gestation, in those whose mothers smoked in pregnancy, or who were in manual occupations. After adjusting for relevant maternal and infant characteristics, infants in the low birth weight for gestation group experienced a mean reduction of 11 ml in FEV0.4 (95% CI 4 to 18; p=0.002), of 12 ml in FVC (95% CI 4 to 19; p=0.004), and of 28 ml/s in MEF25 (95% CI 7 to 48; p=0.03).
conclusionsAirway function is diminished in early postnatal life as a consequence of a complex causal pathway which includes social disadvantage as indicated by maternal social class, smoking and height, birth weight as a proximal and related consequence of these factors, and genetic predisposition to asthma. Further work is needed to establish the relevance of these findings to subsequent airway growth and development in later infancy and early childhood.
Indexed as
Identifiers
14694251PMC1758850W2098979540What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.