ArticleThe Journal of physiology2004
Slow inactivation of the Ca(V)3.1 isotype of T-type calcium channels.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Transcriptomic Atlas of Human Trabecular Meshwork Uncovers the Cellular Landscape and Provides Insights into Glaucoma Pathophysiology.Research square · 2026Article
- T-Type Voltage-Gated Calcium Channels: Potential Regulators of Smooth Muscle Contractility.International journal of molecular sciences · 2024Review
- Evidence for a Physiological Role of T-Type Ca Channels in Ventricular Cardiomyocytes of Adult Mice.Membranes · 2022Article
- The anticonvulsant phytocannabinoids CBGVA and CBDVA inhibit recombinant T-type channels.Frontiers in pharmacology · 2022Article
- A low voltage activated CaChannels (Austin, Tex.) · 2020Article
- Control of transitions between locomotor-like and paw shake-like rhythms in a model of a multistable central pattern generator.Journal of neurophysiology · 2018Article
- A computational model of excitation and contraction in uterine myocytes from the pregnant rat.Scientific reports · 2018Article
- Sodium channel diversity in the vestibular ganglion: NaV1.5, NaV1.8, and tetrodotoxin-sensitive currents.Journal of neurophysiology · 2016Article
- The many faces of T-type calcium channels.Pflugers Archiv : European journal of physiology · 2014Review
- Computational modeling of inhibition of voltage-gated Ca channels: identification of different effects on uterine and cardiac action potentials.Frontiers in physiology · 2014Article
- Fe²⁺ block and permeation of CaV3.1 (α1G) T-type calcium channels: candidate mechanism for non-transferrin-mediated Fe²⁺ influx.Molecular pharmacology · 2012Article
- Bidirectional plasticity in the primate inferior olive induced by chronic ethanol intoxication and sustained abstinence.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- History-dependent Dynamics in a Generic Model of Ion Channels - an Analytic Study.Frontiers in computational neuroscience · 2010Article
- Ca2+ current of frog vestibular hair cells is modulated by intracellular ATP but not by long-lasting depolarisation.European biophysics journal : EBJ · 2007Article
- A numerical approach to ion channel modelling using whole-cell voltage-clamp recordings and a genetic algorithm.PLoS computational biology · 2007Article
- T-type and L-type Ca2+ conductances define and encode the bimodal firing pattern of vestibulocerebellar unipolar brush cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- The ion channel inverse problem: neuroinformatics meets biophysics.PLoS computational biology · 2006Review
- T-type Ca2+ channels encode prior neuronal activity as modulated recovery rates.The Journal of physiology · 2006Article
- Paradoxical potentiation of neuronal T-type Ca2+ current by ATP at resting membrane potential.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T-type calcium channels (the Ca(V)3 channel family) are involved in defining the resting membrane potential and in neuronal activities such as oscillations and rebound depolarization. Their physiological roles depend upon the channel activation and inactivation kinetics. A fast inactivation that stops the ionic flux of calcium in tens of milliseconds has already been described in both native and heterologously expressed channels. Here, using HEK 293 cells expressing the rat Ca(V)3.1 channel and whole-cell voltage clamp, we investigate an additional inactivation process, which can be distinguished from the previously described fast inactivation by its slow time course of recovery from inactivation (tau= 1 s) and by its sensitivity to external calcium. Steady-state slow inactivation is voltage dependent around the resting membrane potential (the potential of half-inactivation (V(0.5)) =-70 mV, slope factor = 7.4 mV) and can reduce the calcium current by up to 50%. Near resting potential, the slow inactivation displays a half-time of induction of tens of seconds. The slow inactivation therefore modulates the availability of T-type calcium channels depending upon recent cell history, providing a mechanism to store information in a time scale of seconds.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.