ReviewJournal of clinical pathology2004
The eicosanoid cascade: possible role in gliomas and meningiomas.
Review in Journal of clinical pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 105 citations in OpenAlex.
- Causal Pathways Linking Gut Microbiota, Serum Metabolites, and Meningioma Risk: A Mendelian Randomization Analysis.Brain and behavior · 2026Article
- Longitudinal Plasma Lipidomics Reveals Distinct Signatures Following Surgery in Patients with Glioblastoma.Metabolites · 2025Article
- Multiparametric MRI along with machine learning predicts prognosis and treatment response in pediatric low-grade glioma.Nature communications · 2025Article
- Metabolic partitioning in the brain and its hijacking by glioblastoma.Genes & development · 2023Review
- Fatty Acids, CD36, Thrombospondin-1, and CD47 in Glioblastoma: Together and/or Separately?International journal of molecular sciences · 2022Review
- Determination of a Tumor-Promoting Microenvironment in Recurrent Medulloblastoma: A Multi-Omics Study of Cerebrospinal Fluid.Cancers · 2020Article
- Recurrence/Regrowth in Grade I Meningioma: How to Predict?Frontiers in oncology · 2020Article
- Eicosanoids and cancer.Clinics (Sao Paulo, Brazil) · 2018Article
- Co-expression of COX-2 and 5-LO in primary glioblastoma is associated with poor prognosis.Journal of neuro-oncology · 2015Article
- Effect of α-tocopheryl succinate on the molecular damage induced by indomethacin in C6 glioma cells.Experimental and therapeutic medicine · 2015Article
- Analysis of a synchronous gliosarcoma and meningioma with long survival: A case report and review of the literature.Surgical neurology international · 2013Article
- Leukotriene B(4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Corticosteroid-use in primary and secondary brain tumour patients: a review.Journal of neuro-oncology · 2012Review
- Is human cytomegalovirus a target in cancer therapy?Oncotarget · 2011Review
- Corticosteroids in brain cancer patients: benefits and pitfalls.Expert review of clinical pharmacology · 2011Review
- Lipids, mitochondria and cell death: implications in neuro-oncology.Molecular neurobiology · 2010Review
- Might salicylate exert benefits against childhood cancer?Ecancermedicalscience · 2010Article
- Analysis of several PLA2 mRNA in human meningiomas.Mediators of inflammation · 2009Article
- Tumor-growth-promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets.Neuro-oncology · 2008Article
- Expression of cell adhesion proteins and proteins related to angiogenesis and fatty acid metabolism in benign, atypical, and anaplastic meningiomas.Journal of neuro-oncology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eicosanoids constitute a large family of biologically active lipid mediators that are produced by two enzyme classes, cyclooxygenases (COX-1 and COX-2) and lipoxygenases (5-LO, 12-LO, and 15-LO). Increasing evidence suggests that in addition to a variety of epithelial malignancies, the two most common types of human brain tumour, gliomas and meningiomas, aberrantly overexpress eicosanoid producing enzymes and release a spectrum of eicosanoids that may promote tumorigenesis and the development of peritumorous brain oedema. Glioma and meningioma cells are killed in vitro and in animal models when exposed to COX-2 and 5-LO inhibitors, and their effectiveness is under investigation in clinical trials for treatment of patients with malignant brain tumours. However, despite research into the role of the eicosanoid cascade in the tumorigenesis of human brain tumours, many important questions remain unanswered. Current and newer agents that specifically target key players of the eicosanoid cascade could change the approach to treating brain tumours, because their benefits may lie in their synergism with conventional cytotoxic treatments and/or with other novel agents targeted against other procarcinogenic pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.