ArticleAntimicrobial agents and chemotherapy2004
Flucytosine resistance is restricted to a single genetic clade of Candida albicans.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Exometabolome variation in the fungal pathogen of humansApplied and environmental microbiology · 2026Article
- Wild-type MIC distributions and epidemiological cutoff values for 5-flucytosine andJAC-antimicrobial resistance · 2024Article
- Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi.Journal of fungi (Basel, Switzerland) · 2021Review
- Intraspecies Transcriptional Profiling Reveals Key Regulators of Candida albicans Pathogenic Traits.mBio · 2021Article
- Molecular Markers of Antifungal Resistance: Potential Uses in Routine Practice and Future Perspectives.Journal of fungi (Basel, Switzerland) · 2021Review
- Population Structure of Candida parapsilosis: No Genetic Difference Between French and Uruguayan Isolates Using Microsatellite Length Polymorphism.Mycopathologia · 2018Article
- Article
- New Horizons in Antifungal Therapy.Journal of fungi (Basel, Switzerland) · 2016Review
- Article
- Detection of FUR1 Gene in 5-Flucytosine Resistant Candida Isolates in Vaginal Candidiasis Patients.Journal of clinical and diagnostic research : JCDR · 2013Article
- Progress in antifungal susceptibility testing of Candida spp. by use of Clinical and Laboratory Standards Institute broth microdilution methods, 2010 to 2012.Journal of clinical microbiology · 2012Review
- Wild-type MIC distributions and epidemiological cutoff values for amphotericin B, flucytosine, and itraconazole and Candida spp. as determined by CLSI broth microdilution.Journal of clinical microbiology · 2012Article
- Microbiological screening of Irish patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy reveals persistence of Candida albicans strains, gradual reduction in susceptibility to azoles, and incidences of clinical signs of oral candidiasis without culture evidence.Journal of clinical microbiology · 2011Article
- Molecular mechanisms of resistance to 5-fluorocytosine in laboratory mutants of Candida glabrata.Mycopathologia · 2011Article
- Mutational analysis of flucytosine resistance in Candida glabrata.Antimicrobial agents and chemotherapy · 2010Article
- Candida albicans: genotyping methods and clade related phenotypic characteristics.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2010Article
- A Ser29Leu substitution in the cytosine deaminase Fca1p is responsible for clade-specific flucytosine resistance in Candida dubliniensis.Antimicrobial agents and chemotherapy · 2009Article
- Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae.Antimicrobial agents and chemotherapy · 2009Article
- Efflux-mediated antifungal drug resistance.Clinical microbiology reviews · 2009Review
- Property differences among the four major Candida albicans strain clades.Eukaryotic cell · 2009Article
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3 authors.
Funding
Abstract
Population studies have revealed that Candida albicans can be separated into five major clades, groups I, II, III, SA, and E. Groups SA and E are highly prevalent in South Africa and Europe, respectively, while group II is excluded from the southwestern portion of the United State. In each geographical locale, several clades exist side by side, suggesting little interclade recombination. These results suggest clade-specific phenotypes. In the present study we demonstrate that resistance to flucytosine (5FC MIC >/= 32 micro g/ml), an antifungal used for the treatment of systemic C. albicans infections, is restricted to clade I. In addition, while 97% of all strains for which 5FC MICs were >/=0.5 micro g per ml were members of group I, only 3% were members of the other groups. 5FC MICs were >/=0.5 micro g per ml for 72% of all group I isolates, while 5FC MICs were >/=0.5 micro g per ml for only 2% of all non-group I isolates. These results demonstrate for the first time the clade specificity of a clinically relevant trait (5FC resistance) and suggest that while intraclade recombination may be common, interclade recombination is rare.
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