ArticleAntimicrobial agents and chemotherapy2004
Growth-inhibitory effect of heparin on Babesia parasites.
Article in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 60 citations in OpenAlex.
- Equine piroplasmosis: an emerging tick-borne threat to equine health.Tropical animal health and production · 2026Review
- Efficacy of enoxacin and levofloxacin againstIranian journal of veterinary research · 2025Article
- Effect of Glycosaminoglycans onApplied and environmental microbiology · 2023Article
- A Novel Thioredoxin-Like Protein ofFrontiers in cellular and infection microbiology · 2022Article
- Compounds from the Medicines for Malaria Venture Box Inhibit In Vitro Growth ofMolecules (Basel, Switzerland) · 2021Article
- Isolation of viable Babesia bovis merozoites to study parasite invasion.Scientific reports · 2021Article
- Myrrh OilPathogens (Basel, Switzerland) · 2020Article
- Evaluation of the in vitro and in vivo inhibitory effect of thymoquinone on piroplasm parasites.Parasites & vectors · 2019Article
- Functional and Structural Resilience of the Active Site Loop in the Evolution of Plasmodium Lactate Dehydrogenase.Biochemistry · 2018Article
- Performance and consistency of a fluorescence-based high-throughput screening assay for use in Babesia drug screening in mice.Scientific reports · 2017Article
- The Cryptosporidium parvum C-Type Lectin CpClec Mediates Infection of Intestinal Epithelial Cells via Interactions with Sulfated Proteoglycans.Infection and immunity · 2016Article
- Optimization of a Fluorescence-Based Assay for Large-Scale Drug Screening against Babesia and Theileria Parasites.PloS one · 2015Article
- Inhibitory effect of allicin on the growth of Babesia and Theileria equi parasites.Parasitology research · 2014Article
- Inhibitory effect of cyclophilin A from the hard tick Haemaphysalis longicornis on the growth of Babesia bovis and Babesia bigemina.Parasitology research · 2013Article
- Inhibitory effects of pepstatin A and mefloquine on the growth of Babesia parasites.The American journal of tropical medicine and hygiene · 2012Article
- Apicoplast-targeting antibacterials inhibit the growth of Babesia parasites.Antimicrobial agents and chemotherapy · 2012Article
- Anti-babesial activity of a potent peptide fragment derived from longicin of Haemaphysalis longicornis.Tropical animal health and production · 2012Article
- A shared antigen among Babesia species: ribosomal phosphoprotein P0 as a universal babesial vaccine candidate.Parasitology research · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the inhibitory effects of three heparins on the growth of Babesia parasites. The multiplication of Babesia bovis, B. bigemina, B. equi, and B. caballi in in vitro cultures and that of B. microti in vivo were significantly inhibited in the presence of heparins, as determined by light microscopy. Treatment with various concentrations of heparin showed complete clearance of the intracellular parasites. Interestingly, a higher percentage of abnormally multidividing B. bovis parasites was observed in the presence of low concentrations of heparin. Furthermore, fluorescein isothiocyanate-labeled heparin was preferably found on the surfaces of extracellular merozoites, as detected by confocal laser scanning microscopy. These findings indicate that the heparin covers the surfaces of babesial merozoites and inhibits their subsequent invasion of erythrocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.