ArticleNature immunology2004
Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis.
Article in Nature immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 127 citations in OpenAlex.
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- Tissue specific innate immune responses impact viral infection in Drosophila.PLoS pathogens · 2024Article
- Symbiotic Bacteria ModulateInternational journal of molecular sciences · 2023Article
- Orally acquired cyclic dinucleotides drive dSTING-dependent antiviral immunity in enterocytes.Cell reports · 2021Article
- Transovarial transmission of a core virome in the Chagas disease vector Rhodnius prolixus.PLoS pathogens · 2021Article
- Physical and Chemical Barriers in the Larval Midgut Confer Developmental Resistance to Virus Infection inViruses · 2021Article
- Viral susceptibility across host species is largely independent of dietary protein to carbohydrate ratios.Journal of evolutionary biology · 2021Article
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- Vector Specificity of Arbovirus Transmission.Frontiers in microbiology · 2021Review
- Cell Lines for Honey Bee Virus Research.Viruses · 2020Review
- Real-time analysis of quantum dot labeled single porcine epidemic diarrhea virus moving along the microtubules using single particle tracking.Scientific reports · 2019Article
- Dicer-2 Regulates Resistance and Maintains Homeostasis against Zika Virus Infection inJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Changes in temperature alter the potential outcomes of virus host shifts.PLoS pathogens · 2018Article
- Bub1 Facilitates Virus Entry through Endocytosis in a Model of Drosophila Pathogenesis.Journal of virology · 2018Article
- Inflammation-Induced, STING-Dependent Autophagy Restricts Zika Virus Infection in the Drosophila Brain.Cell host & microbe · 2018Article
- Article
- Decreased function of survival motor neuron protein impairs endocytic pathways.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A conserved virus-induced cytoplasmic TRAMP-like complex recruits the exosome to target viral RNA for degradation.Genes & development · 2016Article
- In vivo and in vitro infection dynamics of honey bee viruses.Scientific reports · 2016Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The identification of host factors that control susceptibility to infection has been hampered by a lack of amenable genetic systems. We established an in vivo model to determine the host factors that control pathogenesis and identified viral entry as a rate-limiting step for infection. We infected Drosophila melanogaster cells and adults with drosophila C virus and found that the clathrin-mediated endocytotic pathway is essential for both infection and pathogenesis. Heterozygosity for mutations in genes involved in endocytosis is sufficient to protect flies from pathogenicity, indicating the exquisite sensitivity and dependency of the virus on this pathway. Thus, this virus model provides a sensitive and efficient approach for identifying components required for pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.