ArticleProtein science : a publication of the Protein Society2004
Prediction of the odorant binding site of olfactory receptor proteins by human-mouse comparisons.
Article in Protein science : a publication of the Protein Society, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed.
- Extra-nasal odorant receptors: molecular mechanisms and therapeutic implications.Frontiers in physiology · 2026Review
- Molecular Mechanism Analysis of the Activation of Human Olfactory Receptor OR9Q2 by 4-Methylphenol.Foods (Basel, Switzerland) · 2025Article
- Decoding the Molecular Mechanisms of Menthol Isomer Perception Based on Computational Simulations.Foods (Basel, Switzerland) · 2025Article
- Exploring LinearJournal of medicinal chemistry · 2025Article
- Identification of Olfactory Receptors Responding to Androstenone and the Key Structure Determinant in Domestic Pig.Current issues in molecular biology · 2024Article
- Tracking the Diversity and Chromosomal Distribution of the Olfactory Receptor Gene Repertoires of Three Anurans Species.Journal of molecular evolution · 2023Article
- Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1.Journal of chemical information and modeling · 2023Article
- Odor Discrimination by Lipid Membranes.Membranes · 2023Article
- Large-Scale G Protein-Coupled Olfactory Receptor-Ligand Pairing.ACS central science · 2022Article
- Two entry tunnels in mouse TAAR9 suggest the possibility of multi-entry tunnels in olfactory receptors.Scientific reports · 2022Article
- An evolutionary conserved olfactory receptor for foodborne and semiochemical alkylpyrazines.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Citronellal perception and transmission by Anopheles gambiae s.s. (Diptera: Culicidae) females.Scientific reports · 2020Article
- Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3.Cellular and molecular life sciences : CMLS · 2020Article
- Functional Architecture of Deleterious Genetic Variants in the Genome of a Wrangel Island Mammoth.Genome biology and evolution · 2020Article
- Signature of adaptive evolution in olfactory receptor genes in Cory's Shearwater supports molecular basis for smell in procellariiform seabirds.Scientific reports · 2020Article
- Convergent degeneration of olfactory receptor gene repertoires in marine mammals.BMC genomics · 2019Article
- A Highly Selective Biosensor Based on Peptide Directly Derived from the HarmOBP7 Aldehyde Binding Site.Sensors (Basel, Switzerland) · 2019Article
- Is It Possible to Predict the Odor of a Molecule on the Basis of its Structure?International journal of molecular sciences · 2019Review
- Agonists of G-Protein-Coupled Odorant Receptors Are Predicted from Chemical Features.The journal of physical chemistry letters · 2018Article
- Carbon chain shape selectivity by the mouse olfactory receptor OR-I7.Organic & biomolecular chemistry · 2018Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
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Abstract
Olfactory receptors (ORs) are a large family of proteins involved in the recognition and discrimination of numerous odorants. These receptors belong to the G-protein coupled receptor (GPCR) hyperfamily, for which little structural data are available. In this study we predict the binding site residues of OR proteins by analyzing a set of 1441 OR protein sequences from mouse and human. The central insight utilized is that functional contact residues would be conserved among pairs of orthologous receptors, but considerably less conserved among paralogous pairs. Using judiciously selected subsets of 218 ortholog pairs and 518 paralog pairs, we have identified 22 sequence positions that are both highly conserved among the putative orthologs and variable among paralogs. These residues are disposed on transmembrane helices 2 to 7, and on the second extracellular loop of the receptor. Strikingly, although the prediction makes no assumption about the location of the binding site, these amino acid positions are clustered around a pocket in a structural homology model of ORs, mostly facing the inner lumen. We propose that the identified positions constitute the odorant binding site. This conclusion is supported by the observation that all but one of the predicted binding site residues correspond to ligand-contact positions in other rhodopsin-like GPCRs.
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