ArticleThe Journal of cell biology2003
Isoform-specific insulin receptor signaling involves different plasma membrane domains.
Article in The Journal of cell biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 87 citations in OpenAlex.
- Insulin receptor alternative splicing in breast and prostate cancer.Cancer cell international · 2024Review
- Tissue-specific expression of insulin receptor isoforms in obesity/type 2 diabetes mouse models.Journal of cellular and molecular medicine · 2021Article
- Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle.The Journal of clinical investigation · 2021Article
- The Neglected Insulin: IGF-II, a Metabolic Regulator with Implications for Diabetes, Obesity, and Cancer.Cells · 2019Review
- Insulin Antagonizes LPS-Induced Inflammatory Responses by Activating SR-A1/ERK Axis in Macrophages.Inflammation · 2019Article
- Diet-induced β-cell insulin resistance results in reversible loss of functional β-cell mass.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- The beta secretase BACE1 regulates the expression of insulin receptor in the liver.Nature communications · 2018Article
- The packing density of a supramolecular membrane protein cluster is controlled by cytoplasmic interactions.eLife · 2017Article
- Biochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin.Current protocols in chemical biology · 2016Article
- Annexin A6 regulates interleukin-2-mediated T-cell proliferation.Immunology and cell biology · 2016Article
- Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells.Molecular metabolism · 2016Article
- Nephrin Contributes to Insulin Secretion and Affects Mammalian Target of Rapamycin Signaling Independently of Insulin Receptor.Journal of the American Society of Nephrology : JASN · 2016Article
- Obesity and cancer, a case for insulin signaling.Cell death & disease · 2015Review
- New insights into the architecture of the islet of Langerhans: a focused cross-species assessment.Diabetologia · 2015Review
- Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The paired basic amino acid-cleaving enzyme 4 (PACE4) is involved in the maturation of insulin receptor isoform B: an opportunity to reduce the specific insulin receptor-dependent effects of insulin-like growth factor 2 (IGF2).The Journal of biological chemistry · 2015Article
- Insulin signaling: implications for podocyte biology in diabetic kidney disease.Current opinion in nephrology and hypertension · 2015Article
- The extracellular δ-domain is essential for the formation of CD81 tetraspanin webs.Biophysical journal · 2014Article
- Lipid biology of the podocyte--new perspectives offer new opportunities.Nature reviews. Nephrology · 2014Review
- Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates.Cellular and molecular life sciences : CMLS · 2013Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In pancreatic beta-cells, insulin selectively up-regulates the transcription of its own gene and that of the glucokinase gene by signaling through the two isoforms of the insulin receptor, i.e., A-type (Ex11-) and B-type (Ex11+), using different signaling pathways. However, the molecular mechanism(s) that allows the discrete activation of signaling cascades via the two receptor isoforms remains unclear. Here we show that activation of the insulin promoter via A-type and of the glucokinase promoter via B-type insulin receptor is not dependent on receptor isoform-specific differences in internalization but on the different localization of the receptor types in the plasma membrane. Our data demonstrate that localization and function of the two receptor types depend on the 12-amino acid string encoded by exon 11, which acts as a sorting signal rather than as a physical spacer. Moreover, our data suggest that selective activation of the insulin and glucokinase promoters occurs by signaling from noncaveolae lipid rafts that are differently sensitive toward cholesterol depletion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.