ReviewJournal of anatomy2004
Identifying genes for neuron survival and axon outgrowth in Hirudo medicinalis.
Review in Journal of anatomy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Comparative Aspects of Annelid Regeneration: Towards Understanding the Mechanisms of Regeneration.Genes · 2021Review
- Article
- De novo transcriptome assembly databases for the central nervous system of the medicinal leech.Scientific data · 2015Article
- Differentially expressed genes in Hirudo medicinalis ganglia after acetyl-L-carnitine treatment.PloS one · 2013Article
- Marked changes in neuropeptide expression accompany broadcast spawnings in the gastropod Haliotis asinina.Frontiers in zoology · 2012Article
- Multiple changes in peptide and lipid expression associated with regeneration in the nervous system of the medicinal leech.PloS one · 2011Article
- Construction of a medicinal leech transcriptome database and its application to the identification of leech homologs of neural and innate immune genes.BMC genomics · 2010Article
- CRIP homologues maintain apical cytoskeleton to regulate tubule size in C. elegans.Developmental biology · 2008Article
- Differential expression of genes at stages when regeneration can and cannot occur after injury to immature mammalian spinal cord.Cellular and molecular neurobiology · 2005Article
- Hirudo medicinalis: a platform for investigating genes in neural repair.Cellular and molecular neurobiology · 2005Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
We have studied the molecular basis of nervous system repair in invertebrate (Hirudo medicinalis) nerve cells. Unlike in mammals, neurons in invertebrates survive injury and regrow processes to restore the connections that they held before the damage occurred. To identify genes whose expression is regulated after injury, we have used subtractive probes, constructed from regenerating and non-regenerating ganglia from the leech Hirudo medicinalis, to screen cDNA libraries made from whole leech CNS or from identified microdissected neurons. We have identified genes of known or predicted function as well as novel genes. Known genes up-regulated within hours of injury and that are widely expressed in invertebrate and mammalian cells include thioredoxin and tubulin. Other known genes, e.g. Cysteine Rich Intestinal Protein (CRIP), have previously been identified in mammalian cells though not in regenerating adult neurons. Two regulated genes identified, myohemerythrin and the novel protein ReN3 are exclusively expressed in invertebrates. Thus our approach has enabled us to identify genes, present in a neuron of known function, that are up- and down-regulated within hours of axotomy, and that may underpin the intrinsic ability of invertebrate neurons to survive damage and initiate regrowth programmes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.