ArticleThe Journal of cell biology1992
Expression of c-fos and AP-1 activity in senescent human fibroblasts is not sufficient for DNA synthesis.
Article in The Journal of cell biology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 46 citations in OpenAlex.
- Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence.Genome biology · 2018Article
- Article
- The histone deacetylase-3 complex contains nuclear receptor corepressors.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein.Molecular and cellular biology · 2000Article
- A role for RNA helicase A in post-transcriptional regulation of HIV type 1.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts.Molecular and cellular biology · 1994Article
- Adipocyte differentiation selectively represses the serum inducibility of c-jun and junB by reversible transcription-dependent mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Terminal differentiation and senescence in the human melanocyte: repression of tyrosine-phosphorylation of the extracellular signal-regulated kinase 2 selectively defines the two phenotypes.Molecular biology of the cell · 1994Article
- Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human fibroblasts have a limited replicative life span when maintained in culture after which they become unresponsive to treatment with mitogens, a phenomenon most commonly called senescence. Experiments indicating that serum does not induce expression of the c-fos proto-oncogene in senescent fibroblasts raised the issue of a potential central role for c-fos in the phenotype of sustained growth arrest. This was directly tested by microinjection of oncogenic c-Ha-ras protein into senescent fibroblasts. While ras injection was found to induce marked nuclear c-fos expression and functional AP-1 transcription activity, this did not lead to DNA synthesis. These results suggest that the senescence phenotype cannot be solely attributed to the absence of c-fos expression and that the proliferative block in these cells is either independent of AP-1 transcriptional activity, downstream of it, or involves multiple molecular mechanisms.
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