ArticleJournal of the Association for Research in Otolaryngology : JARO2003
Expression of mucins in mucoid otitis media.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- The association between the adenoid microbiome and chronic otitis media with effusion in children differs according to age.Frontiers in cellular and infection microbiology · 2025Article
- Mucin-induced surface dispersal ofmBio · 2024Article
- MUC5B induces in vitro neutrophil extracellular trap formation: Implication in otitis media.Laryngoscope investigative otolaryngology · 2020Article
- DNA Methylation Patterns of Chronic Explosive Breaching in U.S. Military Warfighters.Frontiers in neurology · 2020Article
- Antibiotic modulation of mucins in otitis media; should this change our approach to watchful waiting?International journal of pediatric otorhinolaryngology · 2019Article
- Cellular content plays a crucial role in Non-typeable Haemophilus influenzae infection of preinflamed Junbo mouse middle ear.Cellular microbiology · 2019Article
- Characterization of mucoid and serous middle ear effusions from patients with chronic otitis media: implication of different biological mechanisms?Pediatric research · 2018Article
- Differential diagnosis of otitis media with effusion using label-free Raman spectroscopy: A pilot study.Journal of biophotonics · 2018Article
- Nontypeable Haemophilus influenzae lysates increase heterogeneous nuclear ribonucleoprotein secretion and exosome release in human middle-ear epithelial cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Association of Gel-Forming Mucins and Aquaporin Gene Expression With Hearing Loss, Effusion Viscosity, and Inflammation in Otitis Media With Effusion.JAMA otolaryngology-- head & neck surgery · 2017Article
- The Role of the Notch Signal Pathway in Mucosal Cell Metaplasia in Mouse Acute Otitis Media.Scientific reports · 2017Article
- Purification and characterization of microRNAs within middle ear fluid exosomes: implication in otitis media pathophysiology.Pediatric research · 2017Article
- In vivo imaging of the Muc5b gel-forming mucin.Scientific reports · 2017Article
- Article
- Noninvasive depth-resolved optical measurements of the tympanic membrane and middle ear for differentiating otitis media.The Laryngoscope · 2015Article
- The adenocarcinoma cell surface mucin receptor for alpha-fetoprotein: is the same receptor present on circulating monocytes and macrophages? A commentary.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- Article
- Math1, retinoic acid, and TNF-α synergistically promote the differentiation of mucous cells in mouse middle ear epithelial cells in vitro.Pediatric research · 2013Article
- Mucin production and mucous cell metaplasia in otitis media.International journal of otolaryngology · 2012Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
A hallmark of mucoid otitis media (MOM, i.e., chronic otitis media with mucoid effusion) is mucus accumulation in the middle ear cavity, a condition that impairs transduction of sounds in the ear and causes hearing loss. The mucin identities of mucus and the underlying mechanism for the production of mucins in MOM are poorly understood. In this study, we demonstrated that the MUC5B and MUC4 were major mucins in MOM that formed distinct treelike polymers (mucus strands). The MUC5B and MUC4 mRNAs in the middle ear mucosa with MOM were up regulated 5-fold and 6-fold, compared with the controls. This upregulation was accompanied by the extensive proliferation of the MUC5B- and MUC4-producing cells in the middle ear epithelium. Further study indicated that the mucin hyperproduction was significantly linked to CD4+ and CD8+ T cells and/or CD68+ monocyte macrophages. It suggests that MUC5B and MUC4 expression may be regulated by the products of these cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.