ArticleJournal of the Association for Research in Otolaryngology : JARO2003
Selective expression of beta tubulin isotypes in gerbil vestibular sensory epithelia and neurons.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- TUBB4B is essential for the cytoskeletal architecture of cochlear supporting cells and motile cilia development.Communications biology · 2024Article
- Structural and functional diversity of mitochondria in vestibular/cochlear hair cells and vestibular calyx afferents.Hearing research · 2022Review
- Article
- TheJournal of developmental biology · 2017Article
- Sodium channel diversity in the vestibular ganglion: NaV1.5, NaV1.8, and tetrodotoxin-sensitive currents.Journal of neurophysiology · 2016Article
- Neurosensory Differentiation and Innervation Patterning in the Human Fetal Vestibular End Organs between the Gestational Weeks 8-12.Frontiers in neuroanatomy · 2016Article
- Spatio-temporal dynamics of β-tubulin isotypes during the development of the sensory auditory organ in rat.Histochemistry and cell biology · 2015Article
- Deletion of Shank1 has minimal effects on the molecular composition and function of glutamatergic afferent postsynapses in the mouse inner ear.Hearing research · 2015Article
- Distribution of Na,K-ATPase α subunits in rat vestibular sensory epithelia.Journal of the Association for Research in Otolaryngology : JARO · 2014Article
- Expression and localization of ryanodine receptors in the frog semicircular canal.Journal of biomedicine & biotechnology · 2012Article
- Development of otolith receptors in Japanese quail.Developmental neurobiology · 2010Article
- Mammalian cilia function is independent of the polymeric state of tubulin glycylation.Cell motility and the cytoskeleton · 2007Article
- A mutation in CCDC50, a gene encoding an effector of epidermal growth factor-mediated cell signaling, causes progressive hearing loss.American journal of human genetics · 2007Article
- Direct involvement of the isotype-specific C-terminus of beta tubulin in ciliary beating.Journal of cell science · 2005Article
- Requirement for the betaI and betaIV tubulin isotypes in mammalian cilia.Cell motility and the cytoskeleton · 2003Article
- Cell type-specific reduction of beta tubulin isotypes synthesized in the developing gerbil organ of Corti.Journal of neurocytology · 2003Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The seven mammalian isotypes of beta tubulin are strikingly similar in amino acid sequence. The differences in isotypic sequence, although small, are nonetheless conserved in evolution, which suggests that they may confer distinct functional roles. If so, such roles should be reflected in the selective expression of isotypes by cell type, or even in the sorting of isotypes to within-cell pools. Hair cells of the vestibular sensory epithelia each possess a kinocilium, a microtubule-based organelle that could represent a distinct microtubule compartment, separate from the extensive microtubule network in the soma. The afferent neurons that innervate the vestibular sensory epithelia may also be functionally divided into dendritic, somatic, and axonal compartments, each with its own complement of microtubules. We have examined the distribution of beta tubulin isotypes in gerbil vestibular epithelia using isotype-specific antibodies to four isotypes and indirect immunofluorescence. We found that hair cells selectively express betaI and betaIV tubulin, while supporting cells express betaI, betaII, and betaIV tubulin. However, no sorting of isotypes between somatic and kinocilia compartments was found in hair cells. Vestibular ganglion cells display three isotypes in the soma, axon, and terminal dendrite compartments (betaI, betaII, and betaIII tubulin), but only betaIII tubulin was found in calyceal nerve endings. The implication of these findings is that beta tubulin isotypes are not sorted to within-cell compartments in hair cells but are sorted in some vestibular neurons.
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