ReviewNeurogenetics2004
Friedreich ataxia-update on pathogenesis and possible therapies.
Review in Neurogenetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Investigating the Clinical Significance and Research Discrepancies of Balance Training in Degenerative Cerebellar Disease: A Systematic Review.American journal of physical medicine & rehabilitation · 2020Pooled it
- Utilisation of advance motor information is impaired in Friedreich ataxia.Cerebellum (London, England) · 2011Trial
- How is disease progress in Friedreich's ataxia best measured? A study of four rating scales.Journal of neurology, neurosurgery, and psychiatry · 2007Trial
- Dimethyl fumarate dose-dependently increases mitochondrial gene expression and function in muscle and brain of Friedreich's ataxia model mice.Human molecular genetics · 2021Article
- Therapeutic developments in Friedreich ataxia.Journal of child neurology · 2012Review
- Auditory processing deficits in children with Friedreich ataxia.Journal of child neurology · 2012Article
- Effects of intravenous administration of human umbilical cord blood stem cells in 3-acetylpyridine-lesioned rats.Stem cells international · 2012Article
- Mesenchymal stem cells restore frataxin expression and increase hydrogen peroxide scavenging enzymes in Friedreich ataxia fibroblasts.PloS one · 2011Article
- Modeling neurological disorders by human induced pluripotent stem cells.Journal of biomedicine & biotechnology · 2011Review
- (1)H MR spectroscopy in Friedreich's ataxia and ataxia with oculomotor apraxia type 2.Brain research · 2010Article
- Ocular motor fixation deficits in Friedreich ataxia.Cerebellum (London, England) · 2010Article
- Impairment in motor reprogramming in Friedreich ataxia reflecting possible cerebellar dysfunction.Journal of neurology · 2010Article
- Evaluating the progression of Friedreich ataxia and its treatment.Journal of neurology · 2009Review
- Article
- Phosphorus-31 two-dimensional chemical shift imaging in the myocardium of patients with late onset of Friedreich ataxia.Molecular imaging and biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Friedreich ataxia is the most-common inherited ataxia. Since the causative genetic basis was described in 1996, much has been learnt about the pathogenesis from human, animal, and yeast studies. This has led to the development of rational therapeutic approaches. In this review, the current state of knowledge regarding the pathogenesis of Friedreich ataxia is presented and possible therapeutic strategies based on this knowledge are discussed.
Indexed as
Identifiers
14689254What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.