ArticleJournal of human hypertension2004
Relation between insulin and aortic stiffness: a population-based study.
Article in Journal of human hypertension, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01310088 (Blood Pressure and Central Vascular Stiffness in Obese Children. Relationship to Metabolic Disturbances and Subclinical Cardiovascular Damage. Effect of Weight Reduction), which is not on this map. Cited by 15 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Blood Pressure and Central Vascular Stiffness in Obese Children. Relationship to Metabolic Disturbances and Subclinical Cardiovascular Damage. Effect of Weight Reduction
Who cites it
15 citing papers in PubMed, 59 citations in OpenAlex.
- Effects of long-term almond consumption on markers for vascular function and cardiometabolic risk in men and women with prediabetes: results of a randomized, controlled cross-over trial.European journal of nutrition · 2024Trial
- Effect of glycemic control on markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus: A review.World journal of diabetes · 2021Review
- Effect of physical activity on pulse wave velocity in elderly subjects with normal glucose, prediabetes or Type 2 Diabetes.Scientific reports · 2018Article
- Adiposity measures and arterial stiffness in primary care: the MARK prospective observational study.BMJ open · 2017Observational
- Nondiabetic Glucometabolic Status and Progression of Aortic Stiffness: The Whitehall II Study.Diabetes care · 2017Observational
- Effects of ipragliflozin, a selective sodium-glucose co-transporter 2 inhibitor, on blood pressure in Japanese patients with type 2 diabetes mellitus: a pooled analysis of six randomized, placebo-controlled clinical trials.Diabetology international · 2017Article
- Particle numbers of lipoprotein subclasses and arterial stiffness among middle-aged men from the ERA JUMP study.Journal of human hypertension · 2014Article
- How many measurements are needed to estimate blood pressure variability without loss of prognostic information?American journal of hypertension · 2014Article
- Visceral adiposity index may be a surrogate marker for the assessment of the effects of obesity on arterial stiffness.PloS one · 2014Article
- Vascular Compliance during Insulin Infusion and Oral Glucose Challenge.Artery research · 2013Article
- Insulin Sensitivity and Beta-Cell Function Are Associated with Arterial Stiffness in Individuals without Hypertension.Journal of diabetes research · 2013Article
- Cardiovascular prevention: relationships between arterial aging and chronic drug treatment.Journal of human hypertension · 2011Article
- Pulse wave velocity as a marker of severity of coronary artery disease.Journal of clinical hypertension (Greenwich, Conn.) · 2009Article
- Relationships between pulse wave velocity and heart rate variability in healthy men with a range of moderate-to-vigorous physical activity levels.European journal of applied physiology · 2006Article
- Continuous improvement of arterial compliance beyond blood pressure decrease after 5 years of antihypertensive treatment.Journal of clinical hypertension (Greenwich, Conn.) · 2006Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have suggested that a high pulse wave velocity (PWV), a measure of aortic stiffness, may be a stronger risk factor for cardiovascular disease (CVD) than a high blood pressure (BP). The relation between insulin, believed to play an important role in the development and clinical course of high BP, and PWV is not yet clear. Therefore, we decided to examine the relationship between insulin and PWV in a large population-based study. The study population consisted of a random sample of 1213 women and 1207 men (age range, 41-72 years) without a history of myocardial infarction or stroke. Fasting insulin was determined together with conventional risk factors for CVD. PWV was recorded transcutaneously by a mechanical electrical principle with one transducer positioned over the left common carotid artery, and another over the left femoral artery. In univariate analysis, insulin was highly significantly related to PWV (standardized regression coefficient: 0.0669+/-0.0051; P<0.001). In multivariate analysis, controlling for all well-established predictors of PWV, such as age, systolic BP or mean BP and pulse pressure, sex, and heart rate, as well as controlling for conventional risk factors for CVD and use of BP-lowering drugs, the level of insulin remained a significant predictor of PWV (standardized regression coefficient: 0.0122+/-0.0048; P=0.012). In conclusion, the present study found that a higher insulin level was related to a higher PWV. This indicates that hyperinsulinaemia may affect BP and risk of CVD by increasing aortic stiffness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.