ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2004
Tamponade properties of double-filling with perfluorohexyloctane and silicone oil in a model eye chamber.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Short-Term Total Tamponade with Perfluorocarbon Liquid and Silicone Oil in Complex Rhegmatogenous Retinal Detachment with Severe Proliferative Vitreoretinopathy.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Intraocular perfluorodecalin and silicone oil tamponade (double filling) in the management of complicated retinal detachment: functional and anatomical outcomes using small-gauge surgery.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Vitreous substitutes: the present and the future.BioMed research international · 2014Review
- Ocular tolerance and efficacy of short-term tamponade with double filling of polydimethyloxane and perfluoro-n-octane.Clinical ophthalmology (Auckland, N.Z.) · 2011Article
- Intraocular pressure changes following the use of silicone oil or Densiron 68 as endotamponade in pars plana vitrectomy.Clinical ophthalmology (Auckland, N.Z.) · 2010Article
- [Advantages and disadvantages of heavy silicone oil].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2010Article
- [Densiron-68 heavy silicone oil in cases of PVR. Anatomic and functional outcomes].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2009Article
- The concept of heavy tamponades-chances and limitations.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2008Review
- [New developments in retinal detachment surgery].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2008Review
- The combined use of perfluorohexyloctane (F6H8) and silicone oil as an intraocular tamponade in the treatment of severe retinal detachment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2006Article
- Combined use of perfluorohexyloctane and silicone oil as intraocular tamponade: an in vitro study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2006Article
- An experimental study on the effect of encircling band procedure on silicone oil emulsification.The British journal of ophthalmology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of perfluorohexyloctane as a heavier-than-water tamponade for long-term use is limited by its tendency to dispersion and associated intraocular inflammation. Double-filling with silicone oil and F6H8 produces a united, two-layer bubble, appearing as a single bubble. This has been proposed as a method of improving the utility of F6H8 as a tamponade.
methodsA surface modified polymethylmethacrylate model eye chamber was double-filled with perfluorohexyloctane and silicone oil to approximate a 90% fill. The proportion of silicone oil was increased in a stepwise fashion. A qualitative comparison of surface contact at each stage was made. Chambers with one, two or no indent were used. Dispersion by agitation of the chamber was assessed.
resultsWith less than 20% silicone oil it was difficult to force the two liquids to make contact. With more oil they united in the form of a single bubble joined at an interface. Once joined, the sides of the single bubble were drawn away from the wall of the chamber. As the proportion of silicone oil increased the area of lost contact increased and progressed inferiorly. Compared to F6H8 alone the double-fill reduced dispersion.
conclusionSilicone oil and F6H8 can unite to form a single bubble that changes the effectiveness of either tamponade agent on their own. The double-fill needs to have enough silicone oil to form a single bubble, but this needs to be kept as low as possible to avoid progressive loss of lateral tamponade. It does not provide good simultaneous superior and inferior tamponade. The double-fill reduces dispersion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.