ArticleCellular and molecular life sciences : CMLS2003
Neuronal thread protein regulation and interaction with microtubule-associated proteins in SH-Sy5y neuronal cells.
Article in Cellular and molecular life sciences : CMLS, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Glycation in Alzheimer's Disease and Type 2 Diabetes: The Prospect of Dual Drug Approaches for Therapeutic Interventions.Molecular neurobiology · 2025Review
- Uncovering the intricacies of IGF-1 in Alzheimer's disease: new insights from regulation to therapeutic targeting.Inflammopharmacology · 2025Review
- Mind the Metabolic Gap: Bridging Migraine and Alzheimer's disease through Brain Insulin Resistance.Aging and disease · 2024Review
- Role of DPP-4 and SGLT2 Inhibitors Connected to Alzheimer Disease in Type 2 Diabetes Mellitus.Frontiers in neuroscience · 2021Review
- The Placenta as a Target for Alcohol During Pregnancy: The Close Relation with IGFs Signaling Pathway.Reviews of physiology, biochemistry and pharmacology · 2021Review
- Data-Driven Modeling of Knowledge Assemblies in Understanding Comorbidity Between Type 2 Diabetes Mellitus and Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2020Article
- Aerobic Glycolysis in the Retina: Functional Roles of Pyruvate Kinase Isoforms.Frontiers in cell and developmental biology · 2020Review
- Type 2 Diabetes Mellitus and Alzheimer's Disease: Role of Insulin Signalling and Therapeutic Implications.International journal of molecular sciences · 2018Review
- Pin1 Modulation in Physiological Status and Neurodegeneration. Any Contribution to the Pathogenesis of Type 3 Diabetes?International journal of molecular sciences · 2018Review
- The association between urinary Alzheimer-associated neuronal thread protein and cognitive impairment in late-life depression: a controlled pilot study.International journal of biological sciences · 2018Article
- Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1-42.Oxidative medicine and cellular longevity · 2018Article
- Metabolism-Centric Overview of the Pathogenesis of Alzheimer's Disease.Yonsei medical journal · 2017Review
- Urine AD7c-NTP Predicts Amyloid Deposition and Symptom of Agitation in Patients with Alzheimer's Disease and Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2017Article
- Linking insulin with Alzheimer's disease: emergence as type III diabetes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Review
- Type 3 diabetes is sporadic Alzheimer׳s disease: mini-review.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2014Review
- Brain metabolic dysfunction at the core of Alzheimer's disease.Biochemical pharmacology · 2014Review
- Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease.Current Alzheimer research · 2012Review
- Review
- Role of central nervous system insulin resistance in fetal alcohol spectrum disorders.Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique · 2010Review
- Alzheimer's disease is type 3 diabetes-evidence reviewed.Journal of diabetes science and technology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In Alzheimer's disease (AD), neuronal thread protein (NTP) accumulates in cortical neurons and colocalizes with phospho- tau-immunoreactive cytoskeletal lesions that correlate with dementia. To generate additional information about the potential role of NTP in AD, we characterized its expression and regulation in human SH-Sy5y neuronal cells. Quantitative real-time reverse transcription-polymerase chain reactin and Western blot analysis demonstrated prominent insulin, moderate insulin-like growth factor, type 1 (IGF-1) and minimal nerve growth factor stimulation of NTP expression. In addition, NTP protein was more stable and it progressively accumulated in cells that were stimulated with insulin for 24 or 48 h. Metabolic labeling and phospho-amino acid analysis demonstrated phosphorylation of NTP on Serine residues, 30-60 min after insulin or IGF-1 stimulation, when glycogen synthase kinase 3beta (GSK-3beta) activity would no longer have been suppressed. Kinase inhibitor and in vitro phosphorylation studies demonstrated a role for GSK-3beta in the positive regulation of NTP expression and phosphorylation. Coimmunoprecipitation studies demonstrated physical interactions between NTP and tau or microtubule-associated protein 1b (MAP-1b), and ubiquitin immunoreactivity in NTP immunoprecipitates. In summary, these studies showed that (i) NTP expression is regulated at the level of transcription by insulin and IGF-1 stimulation; (ii) NTP is phosphorylated by GSK-3beta; (iii) NTP can physically interact with tau and MAP-1b and (iv) NTP-MAP complexes are ubiquitinated. The results suggest a functional role for NTP in relation to the turnover or processing of neuronal cytoskeletal proteins, attributes that may be modulated by insulin/IGF-1-mediated signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.