ArticleThe EMBO journal2004
Recruitment of Cdc28 by Whi3 restricts nuclear accumulation of the G1 cyclin-Cdk complex to late G1.
Article in The EMBO journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 77 citations in OpenAlex.
- RNA-specific local translation is patterned by condensates for multinucleate cell growth.Nature cell biology · 2026Article
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- Subscaling of a cytosolic RNA binding protein governs cell size homeostasis in the multiple fission alga Chlamydomonas.PLoS genetics · 2024Article
- Hyperactive Ras disrupts cell size control and a key step in cell cycle entry in budding yeast.Genetics · 2023Article
- Mad3 modulates the GScience advances · 2022Article
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- Stress granules display bistable dynamics modulated by Cdk.The Journal of cell biology · 2021Article
- Review
- Cell-size regulation in budding yeast does not depend on linear accumulation of Whi5.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A transcriptome-wide analysis deciphers distinct roles of G1 cyclins in temporal organization of the yeast cell cycle.Scientific reports · 2019Article
- Cdc48/p97 segregase is modulated by cyclin-dependent kinase to determine cyclin fate during G1 progression.The EMBO journal · 2018Article
- Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast.PLoS biology · 2018Article
- Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.Journal of cell science · 2017Article
- Whi7 is an unstable cell-cycle repressor of the Start transcriptional program.Nature communications · 2017Article
- Two independent S-phase checkpoints regulate appressorium-mediated plant infection by the rice blast fungus Magnaporthe oryzae.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Growth Rate as a Direct Regulator of the Start Network to Set Cell Size.Frontiers in cell and developmental biology · 2017Review
- Kinetic partitioning during de novo septin filament assembly creates a critical G1 "window of opportunity" for mutant septin function.Cell cycle (Georgetown, Tex.) · 2016Article
- Cell-Size Control.Cold Spring Harbor perspectives in biology · 2016Review
- Inntags: small self-structured epitopes for innocuous protein tagging.Nature methods · 2015Article
- Two Cdc2 Kinase Genes with Distinct Functions in Vegetative and Infectious Hyphae in Fusarium graminearum.PLoS pathogens · 2015Article
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The G1 cyclin Cln3 is a key activator of cell-cycle entry in budding yeast. Here we show that Whi3, a negative G1 regulator of Cln3, interacts in vivo with the cyclin-dependent kinase Cdc28 and regulates its localization in the cell. Efficient interaction with Cdc28 depends on an N-terminal domain of Whi3 that is also required for cytoplasmic localization of Cdc28, and for proper regulation of G1 length and filamentous growth. On the other hand, nuclear accumulation of Cdc28 requires the nuclear localization signal of Cln3, which is also found in Whi3 complexes. Both Cln3 and Cdc28 are mainly cytoplasmic during early G1, and become nuclear in late G1. However, Whi3-deficient cells show a distinct nuclear accumulation of Cln3 and Cdc28 already in early G1. We propose that Whi3 constitutes a cytoplasmic retention device for Cln3-Cdc28 complexes, thus defining a key G1 event in yeast cells.
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