ArticleThe EMBO journal2004
Eucaryotic genome evolution through the spontaneous duplication of large chromosomal segments.
Article in The EMBO journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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Who cites it
105 citing papers in PubMed.
- Quantitative comparison of fungal genome assembly strategies using short and long reads from simulated and empirical sequencing data.Microbial genomics · 2026Article
- Segmental duplications and supernumerary chromosomes drive antifungal drug resistance in Candida auris.Nature communications · 2026Article
- Evolution of Highly Repetitive Silk Genes in the Luna Moth, Actias luna.Genome biology and evolution · 2026Article
- Nonredundant roles for paralogous proteins in the yeast glucose-sensing pathway.Molecular biology of the cell · 2026Article
- Interplay Between Ribosomal Gene Deficiency and Calorie Restriction in Shaping Yeast Biosynthetic Capacity.Cells · 2025Article
- Non-redundant roles for paralogous proteins in the yeast glucose-sensing pathway.bioRxiv : the preprint server for biology · 2025Article
- High-quality genome assembly and comparative analysis reveal extensive genomic variation inMicrobial genomics · 2025Article
- Mechanisms of tandem duplication in the cancer genome.DNA repair · 2025Review
- The road less travelled? Exploring the nuanced evolutionary consequences of duplicated genes.Essays in biochemistry · 2022Article
- Imaging Intron Evolution.Methods and protocols · 2022Article
- Can Introns Stabilize Gene Duplication?Biology · 2022Article
- Comprehensive analysis of cis- and trans-acting factors affecting ectopic Break-Induced Replication.PLoS genetics · 2022Article
- Article
- Retention of duplicated genes in evolution.Trends in genetics : TIG · 2022Review
- Cohesin regulates homology search during recombinational DNA repair.Nature cell biology · 2021Article
- Review
- Transposon-mediated telomere destabilization: a driver of genome evolution in the blast fungus.Nucleic acids research · 2020Article
- Genomic Multiplication and Drug Efflux Influence Ketoconazole Resistance inFrontiers in cellular and infection microbiology · 2020Article
- An evolving view of copy number variants.Current genetics · 2019Review
- Aneuploidy Enables Cross-Adaptation to Unrelated Drugs.Molecular biology and evolution · 2019Article
45 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is growing evidence that duplications have played a major role in eucaryotic genome evolution. Sequencing data revealed the presence of large duplicated regions in the genomes of many eucaryotic organisms, and comparative studies have suggested that duplication of large DNA segments has been a continuing process during evolution. However, little experimental data have been produced regarding this issue. Using a gene dosage assay for growth recovery in Saccharomyces cerevisiae, we demonstrate that a majority of the revertant strains (58%) resulted from the spontaneous duplication of large DNA segments, either intra- or interchromosomally, ranging from 41 to 655 kb in size. These events result in the concomitant duplication of dozens of genes and in some cases in the formation of chimeric open reading frames at the junction of the duplicated blocks. The types of sequences at the breakpoints as well as their superposition with the replication map suggest that spontaneous large segmental duplications result from replication accidents. Aneuploidization events or suppressor mutations that do not involve large-scale rearrangements accounted for the rest of the reversion events (in 26 and 16% of the strains, respectively).
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