ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
Distribution of K+-dependent Na+/Ca2+ exchangers in the rat supraoptic magnocellular neuron is polarized to axon terminals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- Folic acid prevents inner hair cell degeneration via genomic stability.Cell death discovery · 2025Article
- Regulation of KInternational journal of molecular sciences · 2022Review
- Differences in Calcium Clearance at Inner Hair Cell Active Zones May Underlie the Difference in Susceptibility to Noise-Induced Cochlea Synaptopathy of C57BL/6J and CBA/CaJ Mice.Frontiers in cell and developmental biology · 2020Article
- Intracellular ZnThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Altered NMDA receptor-evoked intracellular CaThe Journal of physiology · 2017Article
- Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway.Molecular neurodegeneration · 2017Article
- Ca2+ removal by the plasma membrane Ca2+-ATPase influences the contribution of mitochondria to activity-dependent Ca2+ dynamics in Aplysia neuroendocrine cells.Journal of neurophysiology · 2016Article
- An essential role for the K+-dependent Na+/Ca2+-exchanger, NCKX4, in melanocortin-4-receptor-dependent satiety.The Journal of biological chemistry · 2014Article
- Purinergic stimulation of K+-dependent Na+/Ca2+ exchanger isoform 4 requires dual activation by PKC and CaMKII.Bioscience reports · 2013Article
- Enhanced NMDA receptor-mediated intracellular calcium signaling in magnocellular neurosecretory neurons in heart failure rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Separate Ca2+ sources are buffered by distinct Ca2+ handling systems in aplysia neuroendocrine cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Endocytosis of somatodendritic NCKX2 is regulated by Src family kinase-dependent tyrosine phosphorylation.Frontiers in cellular neuroscience · 2013Article
- Regulation of presynaptic calcium in a mammalian synaptic terminal.Journal of neurophysiology · 2012Article
- KIF21A-mediated axonal transport and selective endocytosis underlie the polarized targeting of NCKX2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Identification of the neuromuscular junction transcriptome of extraocular muscle by laser capture microdissection.Investigative ophthalmology & visual science · 2010Article
- Contributions of SERCA pump and ryanodine-sensitive stores to presynaptic residual Ca2+.Cell calcium · 2010Article
- Interleukin-1beta release in the supraoptic nucleus area during osmotic stimulation requires neural function.Journal of neuroendocrinology · 2008Article
- A critical role for the potassium-dependent sodium-calcium exchanger NCKX2 in protection against focal ischemic brain damage.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Target cell-specific involvement of presynaptic mitochondria in post-tetanic potentiation at hippocampal mossy fiber synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons are polarized into compartments such as the soma, dendrites, and axon terminals, each of which has highly specialized functions. To test whether Ca2+ is differently handled in different compartments of a neuron, we investigated Ca2+ clearance mechanisms in somata of supraoptic magnocellular neurosecretory cells (MNCs) and in their axon terminals located in neurohypophyses. Using patch-clamp and microfluorometry techniques, Ca2+ transients were evoked by depolarizing pulses. Endogenous Ca2+ binding ratios (kappaS) and Ca2+ clearance rates were calculated from the decay phases of Ca2+ transients according to the single compartment model. Mean values of kappaS were 79 +/- 2.6 in somata of MNCs and 187 +/- 19 in axon terminals. Ca2+ clearance rate in axon terminals, which were calculated from time derivative of Ca2+ decay and the kappaS values, were approximately threefold higher than in somata. In response to external Na+ reduction, Ca2+ clearance rates were reduced by 65% in axon terminals, but did not change in somata. Immunohistochemical assays confirmed that K+-dependent Na+/Ca2+ exchanger (NCKX2) was specifically localized to neurohypophysial axon terminals and was not found in somata. In somata, inhibition of sarcoendoplasmic reticulum Ca2+-ATPase (SERCA) pumps, mitochondrial Ca2+-uniporter, and plasma membrane Ca2+-ATPase (PMCA) pumps decreased Ca2+ clearance rate by 48, 27, and 21%, respectively. These results suggest that neurohypophysial axon terminals have greater Ca2+ clearance power than somata because of the specific localization of NCKX2, and that Ca2+ clearance in somata of MNCs is mediated by SERCA pumps, mitochondrial uniporter, and PMCA pumps.
Indexed as
Identifiers
14684869PMC6740958W1846867593What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.